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Yusuke　Takatsuru

Yusuke　Takatsuru

    Department of Nutritional Sciences　Professor
    Institute of Life Innovation Studies　Researcher
    Course of Food and Nutritional Sciences　Professor
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Last Updated :2025/06/06

Researcher Information

URL

Research funding number

  • 30446265

ORCID ID

J-Global ID

Research Interests

  • 環境生理学   包括脳ネットワーク   リン酸化   スイッチ   KCC2   発達   障害   オリゴマー   グリシン   脱燐酸化   GABAB受容体   スイッチング   モーダルシフト   lipid raft   クロール   パッチクランプ   クロールトランスポーター   細胞死   聴覚   GABA   Thy1-EYFP(H-line)マウス   健常側相同領域   2光子励起レーザー顕微鏡   局所脳梗塞モデル   In vivo imaging   早期リハビリテーション   
    環境生理学   包括脳ネットワーク   リン酸化   スイッチ   KCC2   発達   障害   オリゴマー   グリシン   脱燐酸化   GABAB受容体   スイッチング   モーダルシフト   lipid raft   クロール   パッチクランプ   クロールトランスポーター   細胞死   聴覚   GABA   Thy1-EYFP(H-line)マウス   健常側相同領域   2...See More

Research Areas

  • Life sciences / Physiology

Academic & Professional Experience

  • 2020/04 - Today  Toyo University食環境科学部健康栄養学科教授
  • 2017/09 - Today  上毛病院医師
  • 2015/02 - 2017/08  Gunma UniversityIntegrative Phisiology, Graduate School of Medicine講師
  • 2009/04 - 2015/01  群馬大学 医学(系)研究科(研究院)助教
  • 2006/04 - 2009/03  National Institute for Physiological Sciences研究員
  • 2006 - 2008  National Institute for Physiological SciencesDepartment of Developmental Physiology特別協力研究員

Association Memberships

  • THE JAPAN GERIATRICS SOCIETY   日本精神神経学会   前橋市医師会   群馬県医師会   日本医師会   日本生理学会   JAPAN SOCIETY FOR DEMENTIA RESEARCH   JAPANESE PSYCHOGERIATRIC SOCIETY   伊香保BSの会（代表）   北米神経科学学会   日本神経科学学会   

Published Papers

Conference Activities & Talks

  • Oxytocin in brest milk regulaytes nurturing behavior in the offspring  [Not invited]
    渡辺俊介; 高橋樹; 内田薫; 森下雄太; 宮崎航; 髙鶴裕介; 西森克彦; 下川哲昭
    第102回日本生理学会大会(APPW2025)  2025/03  Poster presentation
  • 日本酒の嗜好性に対する内側前頭前野の働きと食習慣・食嗜好性の関係  [Not invited]
    石関禎子; 髙橋歩夢; 市川葵彩; 髙須あかね; 髙鶴裕介
    第102回日本生理学会大会（APPW2025）  2025/03  Poster presentation
  • 周産期ストレスマウスの母性行動異常に関わる脳領域の決定  [Not invited]
    髙鶴裕介; 渡辺悠介; 高橋樹; 下川哲昭
    第102回日本生理学会大会（APPW2005）  2025/03  Poster presentation
  • 内側前頭前野の応答は塩分嗜好性や食に関する知識と相関する  [Not invited]
    髙鶴裕介; 関根由華; 大瀬良知子
    第101回日本生理学会大会  2024/03  Oral presentation
  • うどん喫食時の内側前頭前野および背外側前頭前野の活動性は食の嗜好性の影響を受ける  [Not invited]
    山﨑瑚子; 丸橋花恋; 吉田圭佑; 髙鶴裕介
    第101回日本生理学会大会  2024/03  Poster presentation
  • 神経細胞識別コードの可視化：クラスター型プロトカドヘリンの発現解析  [Not invited]
    金子涼輔; 阿部学; 井上(上野) 由紀子; 高鶴裕介; 渡辺雅彦; 崎村建司; 柳川右千夫; 八木健
    Neuro2022（第45回日本神経科学大会/第65回日本神経化学会大会/第32回日本神経回路学会大会）  Poster presentation  沖縄  日本神経科学会
  • 入院を要する女性高齢者のせん妄は気温上昇変化により誘発される  [Not invited]
    髙鶴裕介; 服部徳昭
    第64回日本老年医学会学術集会  2022/06  Oral presentation  大阪  日本老年医学会
  • Functional connectivity between frontal medial cortex and angular gyrus contributes gender and age difference on odor sensitivity.  [Not invited]
    Yusuke Takatsuru; Shunichi Motegi; Tatsuya Nishikata; Keita Yonemochi
    The 99th Annual Meeting of the Physiological Society of Japan  Poster presentation
    Functional connectivity between frontal medial cortex and angular gyrus contributes gender and age difference on odor sensitivity.  [Not invited]Yusuke Takatsuru; Shunichi Motegi; Tatsuya Nishikata; K...See More
  • Visualization of Protocadherin neuronal self-recognition code  [Not invited]
    Ryosuke Kaneko; Manabu Abe; Yusuke Takatsuru; Yukiko U; Inoue; Masahiko
    第44回 日本神経科学大会  2021/07  Poster presentation
  • せん妄症状により救急受け入れを行った高齢者症例の傾向  [Not invited]
    高鶴裕介; 服部徳昭
    第35回日本老年精神医学会  2020/12  Oral presentation
  • “Ultra” long-term effect of early-life-stress  [Not invited]
    高鶴裕介
    第36回日本ストレス学会学術総会  2020/10  Nominated symposium
  • ヨウ素摂取過剰による脳機能への影響の解明  [Not invited]
    天野出月; 高鶴裕介; 原口省吾; 鯉淵典之
    第97回日本生理学会大会  2020/03  Poster presentation
  • 成人発症甲状腺機能低下症モデルマウスにおける機械刺激過敏は 電位依存性カリウムチャネルの減少に伴う侵害受容性線維の過興奮に起因する  [Not invited]
    須田真千子; 髙鶴裕介; 天野出月; 原口省吾; 鯉淵典之
    第97回日本生理学会大会  2020/03  Poster presentation
  • 好みの香りによる嗅覚刺激による嚥下機能回復に向けた基礎的研究  [Not invited]
    髙鶴裕介; 茂木俊一; 米持圭太; 服部徳昭
    第97回日本生理学会大会  2020/03  Oral presentation
  • The Impact of Chronic Excess Iodine Intake in Adult Mice Behavior.  [Not invited]
    Amano I; Takatsuru Y; Haijima A; Haraguchi S; Koibuchi N.
    Endo2020  2020/03  Poster presentation
  • 中沢会上毛病院でせん妄症状により救急受け入れを行った高齢者症例の傾向  [Not invited]
    髙鶴裕介; 服部徳昭
    第27回群馬県救急医療懇談会  2019/09  Oral presentation
  • ニューロンIDの可視化：クラスター型プロトカドヘリンの発現解析
    金子涼輔; 阿部学; 高鶴裕介; 井上(上野) 由紀子; 渡辺雅彦; 崎村建司; 柳川右千夫; 八木健
    第42回日本神経科学大会、第62回日本神経化学会大会  2019/07  Poster presentation
  • Joint RANZCP/JSPN symposium: ‘Innovations in psychiatric continuing professional development’ Training for “hybrid” psychiatrist ～change the career from basic science to bed-side job～  [Not invited]
    Takatsuru Y
    RANZCP2019  2019/05  Public symposium
    Joint RANZCP/JSPN symposium: ‘Innovations in psychiatric continuing professional development’ Training for “hybrid” psychiatrist ～change the career from basic science to bed-side job～  [Not invited]Ta...See More
  • 周産期ストレスマウスに見られる初老期認知機能障害.  [Not invited]
    高鶴裕介
    第37回日本認知症学会学術集会  2018/10  Poster presentation
  • 当院診療患者における多剤耐性細菌感染症の動向.  [Not invited]
    高鶴裕介; 服部徳昭
    第34回北関東病院感染対策談話会  2018/08  Oral presentation
  • 脳梗塞回復期におけるハロペリドールの投与は機能回復を遅延させる.  [Not invited]
    高鶴裕介; 福本幹仁; 天野出月; 三谷和子
    第60回日本老年医学会学術集会  2018/06  Poster presentation
  • 周産期ストレスマウスに見られる認知機能障害.  [Not invited]
    高鶴裕介
    第94回日本生理学会  2018/03  Poster presentation
  • The effect of mild perinatal hypothyroidism in adult female mice behavior.  [Not invited]
    Khairinisa MA; Takatsuru Y; Amano I; Koibuchi N.
    AOTA2016  2017/03  Poster presentation
  • Effects of perinatal mild hypothyroidism on learning and memory function of adult male offspring  [Not invited]
    Amano I; Takatsuru Y; Khairinisa MA; Kokubo M; Haijima A; Koibuchi N.
    AOTA2016  2017/03  Poster presentation
    Effects of perinatal mild hypothyroidism on learning and memory function of adult male offspring  [Not invited]Amano I; Takatsuru Y; Khairinisa MA; Kokubo M; Haijima A; Koibuchi N.AOTA2016  2017/03  P...See More
  • 周産期ストレス暴露により初老期に見られる認知機能低下  [Not invited]
    髙鶴裕介; 蓜島旭; 矢島弘之; Khairinisa MA; 天野出月; 鯉淵典之
    第94回日本生理学会  2017/03  Poster presentation
  • 胎児期におけるプロラクチン曝露は将来の母性行動発現に重要である  [Not invited]
    増田真之佑; 西連寺拓; 天野出月; 髙鶴裕介; 金子涼輔; 下川哲昭; 鯉淵典之
    第94回日本生理学会  2017/03  Poster presentation
  • 海馬初代培養細胞の発達における甲状腺ホルモンの役割の解明  [Not invited]
    矢島弘之; 天野出月; 宮崎航; 髙鶴裕介; 鯉淵典之
    第94回日本生理学会  2017/03  Poster presentation
  • 授乳期のパーフルオロオクタンスルホン酸曝露が学習・記憶機能へ及ぼす影響  [Not invited]
    蓜島旭; 天野出月; 髙鶴裕介; 鯉淵典之
    第94回日本生理学会  2017/03  Poster presentation
  • Iridium complex probe, BMTPDM1, is useful probe for in vivo imaging of oxygen dynamics.  [Not invited]
    Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.
    3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro-Device Engineering (GUMI&AMDE2016)  2016/12  Poster presentation
    Iridium complex probe, BMTPDM1, is useful probe for in vivo imaging of oxygen dynamics.  [Not invited]Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.3rd International Symposium of Gunma University Med...See More
  • Mild perinatal thyroid hormone insufficiency induced learning and memory disorders in adult mice.  [Not invited]
    Amano I; Takatsuru Y; Khairinisa MA; Kokubo M; Haijima A; Koibuchi N
    4th Bandung International Biomolecular Medicine Conference  2016/10  Poster presentation
    Mild perinatal thyroid hormone insufficiency induced learning and memory disorders in adult mice.  [Not invited]Amano I; Takatsuru Y; Khairinisa MA; Kokubo M; Haijima A; Koibuchi N4th Bandung Internat...See More
  • Cognitive function impairment in mouse model of mild perinatal hypothyroidism  [Not invited]
    Khairinisa MA; Takatsuru Y; Amano I; Koibuchi N.
    4th Bandung International Biomolecular Medicine Conference  2016/10  Poster presentation
    Cognitive function impairment in mouse model of mild perinatal hypothyroidism  [Not invited]Khairinisa MA; Takatsuru Y; Amano I; Koibuchi N.4th Bandung International Biomolecular Medicine Conference  ...See More
  • 多光子励起レーザー顕微鏡FVMPE-RSを用いたin vivo imagingの実例  [Not invited]
    高鶴裕介; 金子涼輔; 鯉淵典之
    第63回北関東医学会総会  2016/09  Poster presentation
  • Aripiprazole improves the remodeling of neuronal circuit for functional recovery after stroke in somatosensory cortex  [Not invited]
    Obi K; Takatsuru Y; Amano I; Koibuchi N
    10th FENS  2016/07  Poster presentation
    Aripiprazole improves the remodeling of neuronal circuit for functional recovery after stroke in somatosensory cortex  [Not invited]Obi K; Takatsuru Y; Amano I; Koibuchi N10th FENS  2016/07  Poster pr...See More
  • ニューロンIDの可視化：クラスター型プロトカドヘリンの発現解析  [Not invited]
    金子涼輔; 阿部学; 高鶴裕介; 渡辺雅彦; 崎村建司; 柳川右千夫; 八木健
    第39回日本神経科学大会  2016/07  Poster presentation
  • 幼弱期ストレス負荷を受けた成獣マウスはPentylenetetrazole投与で容易にてんかんが惹起される  [Not invited]
    吉田賢治; 高鶴裕介; 天野出月; 鯉淵 典之
    第39回日本神経科学大会  2016/07  Poster presentation
  • Augmentation of thyroid hormone receptor-mediated transcription and thyroid hormone-induced cerebellar morphogenesis by genistein and daidzein  [Not invited]
    Winda Ariyani; 岩崎俊晴; LuYu; 天野出月; 宮崎航; 高鶴裕介; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
    Augmentation of thyroid hormone receptor-mediated transcription and thyroid hormone-induced cerebellar morphogenesis by genistein and daidzein  [Not invited]Winda Ariyani; 岩崎俊晴; LuYu; 天野出月; 宮崎航; 高鶴裕介;...See More
  • Perfluorooctane sulfonate (PFOS) の早期曝露による甲状腺ホルモン脱ヨード化酵素活性の抑制による小脳機能の抑制  [Not invited]
    岩崎俊晴; 蓜島旭; 宮坂勇平; 荒木修; 栗原光累; LuYu; 天野出月; 高鶴裕介; 下川哲昭; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • 授乳期の異なる時期のパーフルオロオクタンスルホン酸曝露による発達神経毒性影響の比較  [Not invited]
    蓜島旭; 天野出月; 高鶴裕介; 岩崎俊晴; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • 胎仔環境が次世代の母性行動発現を決定する機構の解析  [Not invited]
    西連寺ジェームス拓; 増田真之佑; 天野出月; 高鶴裕介; 金子涼輔; 下川哲昭; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • 局所脳梗塞後の再局在化におけるDHEAの修飾作用  [Not invited]
    小尾紀翔; 高鶴裕介; 天野出月; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • 姿勢反射発達における周産期軽度甲状腺機能低下症の影響  [Not invited]
    小久保倫文; 高鶴裕介; 天野出月; 蓜島旭; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • berrant Brain Function in Mild Perinatal Hypothyroidism Mice  [Not invited]
    Miski Aghnia Khairinisa; 高鶴裕介; 天野出月; 小久保倫文; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • 周産期の甲状腺機能低下は成長後の学習障害を来す  [Not invited]
    天野出月; 高鶴裕介; Miski Aghnia Khairinisa; 小久保倫文; 蓜島旭; 鯉淵典之
    第93回日本生理学会  2016/03  Poster presentation
  • イリジウム錯体を用いた加齢性にともなう脳内酸素動態変化の観察  [Not invited]
    高鶴裕介; 鯉淵典之; 吉原利忠; 飛田成史
    第93回日本生理学会  2016/03  Poster presentation
  • （入澤宏・彩記念ＪＰＳ優秀論文賞シンポジウム・In vivo imagingによって見えてきた生理的条件におけるグリア細胞の脳機能に果たす役割）JPS掲載論文「周産期ストレスモデルにおいてミクログリアの動態が変化していた」に挙げた発見と残っている問題点  [Invited]
    高鶴裕介
    第93回日本生理学会  2016/03  Nominated symposium
  • In vivo imaging of oxygen dynamics in aged-animal brain using iridium complex probe  [Not invited]
    Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.
    7th International Conference on Advanced Micro-Device Engineering (AMDE2015)  2015/12  Oral presentation
    In vivo imaging of oxygen dynamics in aged-animal brain using iridium complex probe  [Not invited]Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.7th International Conference on Advanced Micro-Device E...See More
  • 授乳期の異なる時パーフルオロクタンスホ酸（PFOS）曝露が成熟後仔マウスの協調運動機能および学習へ及ぼす影響比較  [Not invited]
    蓜島旭; 天野出月; 高鶴裕介; 岩崎俊晴; 鯉淵典之
    第18回環境ホルモン学会  2015/12  Poster presentation
  • The neuronal and glial reorganization in the intact hemisphere contributes functional remodeling after focal stroke  [Not invited]
    Yusuke Takatsuru; Junichi Nabekura; Noriyuki Koibuchi
    8th FAOPS  2015/11  Poster presentation
    The neuronal and glial reorganization in the intact hemisphere contributes functional remodeling after focal stroke  [Not invited]Yusuke Takatsuru; Junichi Nabekura; Noriyuki Koibuchi8th FAOPS  2015/1...See More
  • Altered cerebellar development of mice deficient in dual oxidase maturation factors.  [Not invited]
    Amano I; Takatsuru Y; Toya S; Haijima A; Iwasaki T; Grasberger H; Refetoff S; Koibuchi N
    ATA 15th International Thyroid Congress  2015/10  Poster presentation
    Altered cerebellar development of mice deficient in dual oxidase maturation factors.  [Not invited]Amano I; Takatsuru Y; Toya S; Haijima A; Iwasaki T; Grasberger H; Refetoff S; Koibuchi NATA 15th Inte...See More
  • The Effect of Perinatal Mild Hypothyroidism in Adult Mice Behavior  [Not invited]
    Miski A. Khairinisa; Yusuke Takatsuru; Izuki Amano; Noriyuki Koibuchi
    第62回北関東医学会総会  2015/10  Poster presentation
  • 運動神経発達に対する甲状腺ホルモンの役割  [Not invited]
    小久保倫文; 高鶴裕介; 天野出月; 蓜島旭; 鯉淵典之
    第62回北関東医学会総会  2015/10  Poster presentation
  • 周産期の軽度甲状腺機能低下により成体マウスで観察された学習障害  [Not invited]
    天野出月; 高鶴裕介; Miski Aghnia Khairinisa; 小久保倫文; 蓜島旭; 鯉淵典之
    第62回北関東医学会総会  2015/10  Poster presentation
  • 周産期ストレス負荷が脳機能に及ぼす長期影響：神経内分泌学的観点で見た世代伝搬  [Not invited]
    髙鶴裕介; 戸谷秀太郎; 三谷秀平; 小久保倫文; 天野出月; 蓜島旭; 鯉淵典之
    第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会・合同学術集会  2015/09  Poster presentation
  • 抑制性ニューロン赤色標識マウス  [Not invited]
    金子涼輔; 髙鶴裕介; 柳川右千夫
    第38回日本神経科学大会  2015/07  Poster presentation
  • Early life stress induced the retardation of cerebellar function in adulthood  [Not invited]
    Takatsuru Y; Kokubo M; Toya S; Amano I; Koibuchi N.
    7th international symposium of SRC  2015/05  Poster presentation
    Early life stress induced the retardation of cerebellar function in adulthood  [Not invited]Takatsuru Y; Kokubo M; Toya S; Amano I; Koibuchi N.7th international symposium of SRC  2015/05  Poster prese...See More
  • Disruption of Glucocorticoid Homeostasis and Glutamatergic Neuronal Circuit in Adulthood of Male Mice By Maternal Deprivation  [Not invited]
    Koibuchi N; Toya S; Amano I; Shimokawa N; Takatsuru Y
    ENDO2015  2015/03  Poster presentation
    Disruption of Glucocorticoid Homeostasis and Glutamatergic Neuronal Circuit in Adulthood of Male Mice By Maternal Deprivation  [Not invited]Koibuchi N; Toya S; Amano I; Shimokawa N; Takatsuru YENDO201...See More
  • パーフルオロオクタンスルホン酸の授乳期曝露が成熟後仔マウスの視覚弁別課題遂行に及ぼす影響  [Not invited]
    蓜島旭; 髙鶴裕介; 天野出月; 鯉淵典之
    第92回日本生理学会  2015/03  Poster presentation
  • 幼弱期ストレス負荷マウスにおけるPentylenetetrazole投与時の易てんかん惹起性  [Not invited]
    吉田賢治; 髙鶴裕介; 天野出月; 鯉淵典之
    第92回日本生理学会  2015/03  Poster presentation
  • 幼弱期ストレスはグルタミン酸作動性シナプスの恒常性を破綻させる  [Not invited]
    戸谷秀太郎; 髙鶴裕介; 小久保倫文; 天野出月; 下川昭哲; 鯉淵典之
    第92回日本生理学会  2015/03  Poster presentation
  • 周産期の甲状腺ホルンモン低下による小脳プルキンエ細胞の変化  [Not invited]
    小久保倫文; 髙鶴裕介; 天野出月; 鯉淵典之
    第92回日本生理学会  2015/03  Poster presentation
  • 周産期の軽度甲状腺機能低下により成体マウスで観察された学習障害  [Not invited]
    天野出月; 髙鶴裕介; Khairinisa Miski Aghnia; 小久保倫文; 蓜島旭; 鯉淵典之
    第92回日本生理学会  2015/03  Poster presentation
  • （シンポジウム・周産期ストレスと脳機能）母子乖離ストレスを受けたメスマウスの母性行動  [Not invited]
    髙鶴裕介
    第92回日本生理学会  2015/03  Public symposium
  • In vivo deep, red color imaging using advanced multi-photon laser microscopy (FVMPE-RS, Olympus)  [Not invited]
    Takatsuru Y; Kaneko R; Kominato Y; Noriyuki K
    International Society of Radiation Neurobiology 5th Conference  2015/02  Poster presentation
    In vivo deep, red color imaging using advanced multi-photon laser microscopy (FVMPE-RS, Olympus)  [Not invited]Takatsuru Y; Kaneko R; Kominato Y; Noriyuki KInternational Society of Radiation Neurobiol...See More
  • In vivo imaging of oxygen dynamics using Iridium complex probe  [Not invited]
    Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.
    1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering (GUMI&AMDE2014)  2014/12  Poster presentation
    In vivo imaging of oxygen dynamics using Iridium complex probe  [Not invited]Takatsuru Y; Koibuchi N; Yoshihara T; Tobita M.1st International Symposium of Gunma University Medical Innovation and 6th I...See More
  • 授乳期のパーフルオロオクタンスルホン酸曝露が自発的物体再認記憶へ及ぼす影響  [Not invited]
    蓜島旭; 高鶴裕介; 天野出月; 鯉淵典之
    第17回環境ホルモン学会  2014/12  Poster presentation
  • In vivo microdialysisを応用した病態生理学研究の実例‐記念誌掲載内容をご紹介‐  [Invited]
    髙鶴裕介
    第25回マイクロダイアリシス研究会  2014/12  Invited oral presentation
  • Cerebellar ataxia in dual oxidase maturation factor (DUOXA) mutant mice  [Not invited]
    Amano I; Takatsuru Y; Toya S; Haijima A; Koibuchi N
    3rd Bandung International biomolecule medicine conference  2014/09  Poster presentation
    Cerebellar ataxia in dual oxidase maturation factor (DUOXA) mutant mice  [Not invited]Amano I; Takatsuru Y; Toya S; Haijima A; Koibuchi N3rd Bandung International biomolecule medicine conference  2014...See More
  • 母子乖離モデルを用いた慢性ストレスの研究－初めまして－  [Not invited]
    髙鶴裕介; 蓜島旭; 天野出月; 戸谷秀太郎; 三谷秀平; 吉田賢治; 下川昭哲; 鯉淵典之
    第21回日本行動神経内分泌学研究会全国集会  2014/09  Oral presentation
  • 群馬大学における多光子励起レーザー顕微鏡の運用実例  [Not invited]
    髙鶴裕介; 金子涼輔; 鯉淵典之
    第61回北関東医学会総会  2014/09  Poster presentation
  • Early life stress affects the homeostasis of glutamatergic neuronal circuit  [Not invited]
    Takatsuru Y; Toya S; Amano I; Shimokawa N; Koibuchi N
    9th FENS  2014/07  Poster presentation
  • 健常半球における脳梗塞後の機能代償に対するグルタミン酸トランスポーターの役割  [Not invited]
    髙鶴裕介; 金子涼輔; 小尾紀翔; 下川哲昭; 鍋倉淳一; 鯉淵典之
    第91回日本生理学会  2014/03  Poster presentation
  • 先天性甲状腺機能低下症マウスにおいて、Parallel fiber-Purkinjeシナプスの短期可塑性に異常が見られた  [Not invited]
    天野出月; 髙鶴裕介; 戸谷秀太郎; 蓜島旭; 鯉淵典之
    第91回日本生理学会  2014/03  Poster presentation
  • 胎児期・授乳期の水酸化PCB曝露が成熟後仔マウスの自発運動量へ及ぼす影響  [Not invited]
    蓜島旭; 下川哲昭; 髙鶴裕介; 天野出月; レスマナ ロニー; 鯉淵典之
    第91回日本生理学会  2014/03  Poster presentation
  • 脳梗塞回復期の健常半球におけるアストロサイトの役割  [Not invited]
    髙鶴裕介; 鍋倉淳一; 鯉淵典之
    第87回日本薬理学会年会  2014/03  Public symposium
  • 新たな機序によるPerfluorooctane sulfonate (PFOS)の脳発達への影響  [Not invited]
    岩崎俊晴; 蓜島旭; 宮坂勇平; Yu Lu; 高鶴裕介; 下川哲昭; 鯉淵典之
    第16回環境ホルモン学会  2013/12  Poster presentation
  • 周産期の水酸化PCB曝露が成熟後仔マウスの自発運動量へ及ぼす影響  [Not invited]
    蓜島旭; 下川哲昭; 高鶴裕介; 天野出月; レスマナロニー; 鯉淵典之
    第16回環境ホルモン学会  2013/12  Poster presentation
  • 脳梗塞後の機能代償における健常半球の役割  [Invited]
    髙鶴裕介
    第60回北関東医学会総会  2013/09  Invited oral presentation
  • 幼弱期ストレスにより生じるグルタミン酸受容体発現量の変化  [Not invited]
    戸谷秀太郎; 髙鶴裕介; 天野出月; 鯉淵典之
    第60回北関東医学会総会  2013/09  Poster presentation
  • 周産期水酸化PCB曝露が成熟後仔マウスの運動協調機能へ及ぼす影響  [Not invited]
    蓜島旭; 下川哲昭; 髙鶴裕介; 天野出月; レスマナロニー; 鯉淵典之
    第60回北関東医学会総会  2013/09  Poster presentation
  • 胎児期・授乳期の低容量水酸化PCB曝露が成熟後仔マウスへ及ぼす影響
    蓜島旭; 下川哲昭; 髙鶴裕介; 天野出月; レスマナロニー; 鯉淵典之
    第40回日本毒性学会大会  2013/06  Poster presentation
  • 脳梗塞後急性期のハロペリドールの投与は機能回復を遅延させる  [Not invited]
    髙鶴裕介; 天野出月; 鯉淵典之
    第36回日本神経科学大会  2013/06  Poster presentation
  • 脳発達におけるPerfluorooctane sulfonate (PFOS)とPerfluorooctanoic acid (PFOA)の影響  [Not invited]
    Iwasaki et
    87th annualmeeting of Japan endcrine society  2013/04  Oral presentation
  • Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid (rdw) rat  [Not invited]
    Hayashi et a
    The 90th annual meeting for the physiological society of Japan  2013/03  Poster presentation
    Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid (rdw) rat  [Not invited]Hayashi et aThe 90th annual meeting for the physiological society of Japan  2013/03 ...See More
  • Aberrant cerebellar development of mice deficient in dual oxidase matuirration factors (DUOXA)  [Not invited]
    Amano I; Takatsuru Y; Haijima A; Koibuch N
    The 90th annual meeting for the physiological society of Japan  2013/03  Poster presentation
    Aberrant cerebellar development of mice deficient in dual oxidase matuirration factors (DUOXA)  [Not invited]Amano I; Takatsuru Y; Haijima A; Koibuch NThe 90th annual meeting for the physiological soc...See More
  • Maternal behavior of female mice exposed to early life stress  [Not invited]
    MItani S; Takatsuru Y; Amano I; Koibuchi N
    The 90th annual meeting for the physiological society of Japan  2013/03  Poster presentation
    Maternal behavior of female mice exposed to early life stress  [Not invited]MItani S; Takatsuru Y; Amano I; Koibuchi NThe 90th annual meeting for the physiological society of Japan  2013/03  Poster pr...See More
  • The moelcular mechanism of early life stress for synaptic instability in somatosensory coretx  [Not invited]
    Toya S; Takatsuru Y; Amano I; Koibuchi N
    The 90th annual meeting for the physiological society of Japan  2013/03  Poster presentation
    The moelcular mechanism of early life stress for synaptic instability in somatosensory coretx  [Not invited]Toya S; Takatsuru Y; Amano I; Koibuchi NThe 90th annual meeting for the physiological societ...See More
  • Role of the glial glutamate transporters for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke  [Not invited]
    Takatsuru Y; Kaneko R; Shimokawa N; Nabekura J; Koibuchi N
    The 90th annual meeting of the physiological society of Japan  2013/03  Poster presentation
    Role of the glial glutamate transporters for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke  [Not invited]Takatsuru Y; Kaneko R; Shimokawa N; Nabekura J; Koibuc...See More
  • Early life stress induced synaptic instability and molecular changes in somatosensory cortex.  [Not invited]
    Takatsuru Y; Toya S; Amano I; Nabekura J; Koibuchi N
    The 23rd CDB meeting: Building multicellular systems from cellular cross-talk  2013/01  Poster presentation
    Early life stress induced synaptic instability and molecular changes in somatosensory cortex.  [Not invited]Takatsuru Y; Toya S; Amano I; Nabekura J; Koibuchi NThe 23rd CDB meeting: Building multicell...See More
  • Study of chronic stress model mice using in vivo microdialysis  [Not invited]
    Yusuke Takatsuru
    The 23th microdialysis meeting  2012/12  Oral presentation
  • The early life stress induced synaptic instability in somatosensory cortex.  [Not invited]
    Takatsuru Y; Toya S; Amano I; Nabekura J; Koibuchi N
    International Synapse Research Workshop 2012  2012/11  Poster presentation
    The early life stress induced synaptic instability in somatosensory cortex.  [Not invited]Takatsuru Y; Toya S; Amano I; Nabekura J; Koibuchi NInternational Synapse Research Workshop 2012  2012/11  Pos...See More
  • Aberrant cerebellar development in dual oxidase maturation factor (DUOXA) knockout mice  [Not invited]
    Izuki Amano; Yusuke Takatsuru; Asahi Haijima; Noriyuki Koibuchi
    AOTA2012  2012/10  Poster presentation
    Aberrant cerebellar development in dual oxidase maturation factor (DUOXA) knockout mice  [Not invited]Izuki Amano; Yusuke Takatsuru; Asahi Haijima; Noriyuki KoibuchiAOTA2012  2012/10  Poster presentat...See More
  • The mechanism of maternal-separation stress for synaptic instability in somatosensory cortex  [Not invited]
    Yusuke Takatsuru; Shu-taro Toya; Hiroko Masuda; Izuki Amano; Noriyuki Koibuchi; Junichi Nabekura
    Neurosicence 2012  2012/09  Poster presentation
    The mechanism of maternal-separation stress for synaptic instability in somatosensory cortex  [Not invited]Yusuke Takatsuru; Shu-taro Toya; Hiroko Masuda; Izuki Amano; Noriyuki Koibuchi; Junichi Nabek...See More
  • Synaptic instability is induced by Mmaternal -separation in somatosensory cortex.  [Not invited]
    Yusuke Takatsuru; Shu-taroh, Toya; Junichi Nabekura; Noriyuki Koibuchi
    8th FENS  2012/07  Poster presentation
    Synaptic instability is induced by Mmaternal -separation in somatosensory cortex.  [Not invited]Yusuke Takatsuru; Shu-taroh, Toya; Junichi Nabekura; Noriyuki Koibuchi8th FENS  2012/07  Poster presenta...See More
  • Maternal exposure of OH-PCB causes hyperactivity in neonatal rats  [Not invited]
    Yusuke TakatsuruYusuke Takatsuru; Shu-taro Toya; Hiroko Masuda; Izuki Amano; Noriyuki Koibuchi; Junichi Nabekura
    The 89th annual meeting of the physiological society of Japan  2012/03  Poster presentation
    Maternal exposure of OH-PCB causes hyperactivity in neonatal rats  [Not invited]Yusuke TakatsuruYusuke Takatsuru; Shu-taro Toya; Hiroko Masuda; Izuki Amano; Noriyuki Koibuchi; Junichi NabekuraThe 89th...See More
  • Maternal exposure of OH-PCB causes hyperactivity in neonatal rats.  [Not invited]
    N. Shimokawa; R. Tosmana; Y. Takatsuru; T. Iwasaki; N. Koibuchi
    The 14th annual meeting of Japan society of endocrine disrupters research.  2011/12  Poster presentation
    Maternal exposure of OH-PCB causes hyperactivity in neonatal rats.  [Not invited]N. Shimokawa; R. Tosmana; Y. Takatsuru; T. Iwasaki; N. KoibuchiThe 14th annual meeting of Japan society of endocrine di...See More
  • Maternal exposure to a PCB metabolite (OH-PCB106) induces hyperactive disorder in neonatal rats.  [Not invited]
    N. Koibuchi; R. Ronny; T. Iwasaki; Y. Takatsuru; N. Shimokawa
    Neuroscience2011  2011/11  Poster presentation
    Maternal exposure to a PCB metabolite (OH-PCB106) induces hyperactive disorder in neonatal rats.  [Not invited]N. Koibuchi; R. Ronny; T. Iwasaki; Y. Takatsuru; N. ShimokawaNeuroscience2011  2011/11  P...See More
  • Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat  [Not invited]
    Sayo Yamaguchi; Asuka Ohsawa; Behnaz Yousefi; Shiori Morioka; Hiroko Masuda; Ronny Ronny; Hideka Hayashi; Yusuke Takatsuru; Toshiharu Iwasaki; Noriaki Shimokawa; Motoaki Umezu; Noriyuki Koibuchi
    4th International Symposium, Society for Research on the Cerebellum  2011/09  Poster presentation
    Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat  [Not invited]Sayo Yamaguchi; Asuka Ohsawa; Behnaz Yousefi; Shiori Morioka; Hiroko Masuda; Ronny Ronny; Hideka Hayash...See More
  • Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction.  [Not invited]
    Yusuke Takatsuru; Noriyuki Koibuchi; Junichi Nabekura
    The 34th Annual meeting of the Japan Neuroscience Society.  2011/09  Poster presentation
    Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction.  [Not invited]Yusuke Takatsuru; Noriyuki Koibuchi; Junichi NabekuraThe 34th Annual meeting of the Japan ...See More
  • PDGFR- β is essential for recruitment, but not for survival of pericyte in adult  [Not invited]
    Jie Shen; Yoko Ishii; Guihua Xu; Takeru Hamashima; Takako Matsushima; Seiji Yamamoto; Yuichi Hattori; Yusuke Takatsuru; Junichi Nabekura; Masakiyo Sasahara
    The 34th Annual meeting of the Japan Neuroscience Society.  2011/09  Oral presentation
    PDGFR- β is essential for recruitment, but not for survival of pericyte in adult  [Not invited]Jie Shen; Yoko Ishii; Guihua Xu; Takeru Hamashima; Takako Matsushima; Seiji Yamamoto; Yuichi Hattori; Yus...See More
  • Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat  [Not invited]
    Sayo Yamaguchi; Asuka Ohsawa; Hiroko Masuda; Yusuke Takatsuru; Noriaki Shimokawa; Noriyuki Koibuchi
    The 88th Annual meeting of the Physiological Society of Japan  2011/03  Poster presentation
    Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat  [Not invited]Sayo Yamaguchi; Asuka Ohsawa; Hiroko Masuda; Yusuke Takatsuru; Noriaki Shimokawa; Noriyuki KoibuchiThe ...See More
  • Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction  [Not invited]
    Yusuke Takatsuru; Noriyuki Koibuchi; Junichi Nabekura
    The 88th Annual meeting of the Physiological Society of Japan  2011/03  Poster presentation
    Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction  [Not invited]Yusuke Takatsuru; Noriyuki Koibuchi; Junichi NabekuraThe 88th Annual meeting of the Physiol...See More
  • Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex.  [Not invited]
    Takatsuru, Y; Fukumoto, D; Yoshitomo, M; Nemoto, T; Tsukada, H; Koibuchi, N; Nabekura, J
    7th FENS  2010/07  Poster presentation
    Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex.  [Not invited]Takatsuru, Y; Fukumoto, D; Yoshitomo, M; Nemoto, T; Tsukada, H; Koibuchi, N...See More
  • The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex.  [Not invited]
    Takatsuru, Y; Fukumoto, D; Yoshitomo, M; Nemoto, T; Tsukada, H; Nabekura, J
    IUPS2009  2009/07  Poster presentation
    The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex.  [Not invited]Takatsuru, Y; Fukumoto, D; Yoshitomo, M; Nemoto, T; Tsukada, ...See More
  • The dendritic spine of layer V pyramidal neuron in contralateral area of focal ischemia was actively remodeling in somatosensory cortex.  [Not invited]
    Yusuke TakatsuruYusuke Takatsuru; Tomomi Nemoto; Junichi Nabekura
    Neuroscience 2008  2008/11  Poster presentation
    The dendritic spine of layer V pyramidal neuron in contralateral area of focal ischemia was actively remodeling in somatosensory cortex.  [Not invited]Yusuke TakatsuruYusuke Takatsuru; Tomomi Nemoto; ...See More
  • The stress of mother-separation cause significant effects for development of dendritic spines in layer V pyramidal neuron in motor cortex.  [Not invited]
    Yusuke Takatsuru; Junichi Nabekura
    The 31th Annual meeting of the Japan Neuroscience Society.  2008/07  Poster presentation
    The stress of mother-separation cause significant effects for development of dendritic spines in layer V pyramidal neuron in motor cortex.  [Not invited]Yusuke Takatsuru; Junichi NabekuraThe 31th Annu...See More
  • Functional roles of glutamate transporters in cerebellar Purkinje cell synapses  [Not invited]
    Iino, M; Takayasu, Y; Takatsuru, Y; Ozawa, S
    The 85th Annual meeting of the Physiological Society of Japan  2008/03  Poster presentation
    Functional roles of glutamate transporters in cerebellar Purkinje cell synapses  [Not invited]Iino, M; Takayasu, Y; Takatsuru, Y; Ozawa, SThe 85th Annual meeting of the Physiological Society of Japan ...See More
  • Regulation of excitatory synaptic transmisson by glial glutamate transporters  [Not invited]
    Takatsuru, Y; Takayasu, Y; Iino, M; Ozawa, S
    The 29th Annual meeting of the Japan Neuroscience Society  2006/07  Poster presentation
    Regulation of excitatory synaptic transmisson by glial glutamate transporters  [Not invited]Takatsuru, Y; Takayasu, Y; Iino, M; Ozawa, SThe 29th Annual meeting of the Japan Neuroscience Society  2006/...See More
  • Regulation of excitatory synaptic transmission by glial glutamate transporters  [Not invited]
    Takatsuru, Y; Takayasu, Y; Iino, M; Ozawa, S
    The 83nd Annual meeting of the Physiological Society of Japan.  2006/03  Nominated symposium
    Regulation of excitatory synaptic transmission by glial glutamate transporters  [Not invited]Takatsuru, Y; Takayasu, Y; Iino, M; Ozawa, SThe 83nd Annual meeting of the Physiological Society of Japan. ...See More
  • glutamate transporter, GLT-1, in climbing fibber-Purkinje cell synapses in the cerebellum.  [Not invited]
    Yusuke TakatsuruTakatsuru, Y; Takayasu, Y; Nikkuni, O; Iino, M; Ozawa, S
    The 82nd Annual meeting of the Physiological Society of Japan.  2005/05  Poster presentation
    glutamate transporter, GLT-1, in climbing fibber-Purkinje cell synapses in the cerebellum.  [Not invited]Yusuke TakatsuruTakatsuru, Y; Takayasu, Y; Nikkuni, O; Iino, M; Ozawa, SThe 82nd Annual meeting...See More
  • C-terminal cytoplasmic domain for expression of functional NMDA receptors in PC12 cells  [Not invited]
    Yusuke TakatsuruTakatsuru, Y; Tsuzuki, K; Okado, H; Miwa A; Ozawa, S
    The 81st Annual meeting of the Physiological Society of Japan  2004/06  Poster presentation
    C-terminal cytoplasmic domain for expression of functional NMDA receptors in PC12 cells  [Not invited]Yusuke TakatsuruTakatsuru, Y; Tsuzuki, K; Okado, H; Miwa A; Ozawa, SThe 81st Annual meeting of the...See More

MISC

Awards & Honors

  • 2017/03 第9回群馬大学医師会賞
     
    受賞者: 高鶴裕介
  • 2016/07 ひらめきときめきサイエンス推進賞
     
    受賞者: 高鶴裕介
  • 2016/03 第6回入澤宏・彩記念ＪＰＳ優秀論文賞
     
    受賞者: 高鶴裕介
  • 2014/12 ベストティーチャー石井賞
     
    受賞者: 高鶴裕介
  • 2013/09 第17回北関東医学会奨励賞
     
    受賞者: 高鶴裕介
  • 2013/03 Physiological society of Japan Kiichi Sagawaaward
     
    受賞者: Yusuke Takatsuru

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2023/04 -2027/03 
    Author : 高鶴 裕介; 下川 哲昭
    Elucidation of the mechanism of parental abandonment caused by perinatal stressJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (from‐to) : 2023/04 -2027/03 Author...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2020/09 -2022/03 
    Author : Takatsuru Yusuke
     
    In order to study the relationship between food preference and brain function, we conducted experiments on fMRI and fNIRS for healthy volunteers. The sensitivity of the smell is more significant in women, and the function decreases in both sexes in age dependence. FMRI experiments show that the sex difference and age-dependent functional changes are particularly involved in the functional connectivity of the frontal medial cortex and angular gyrus. In addition, a study using fNIRS suggested that there may be differences in frontal lobe function at the time of eating depending on the living environment (whether it is with the family or alone) and the preference of the usual food (whether they like the salty taste or the mild taste). In the future, we plan to expand the number of subjects to continue the fNIRS experiment.
    Basic study for improving a nutritional condition using mental effect of eatingJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (from‐to) : 2020/09 -2022/03 Author...See More
  • 周産期ストレスに起因する思春期精神疾患発症メカニズムの解明
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    Date (from‐to) : 2017/04 -2018/03 
    Author : 高鶴 裕介
     
    周産期のストレスが脳の正常な発達を妨げ、うつ病を代表とする精神疾患の罹患率を上げることが知られている。このような変化は動物実験においても再現されているが、その背景にあるメカニズムは未解明である。 研究代表者らはこれまで、母仔乖離マウス（Maternal deprivationマウス; MDマウス）を用いた研究を通じて、周産期ストレスがグルタミン酸恒常性の破綻やシナプスの不安定化を引き起すことを示してきた（Takatsuru et al., 2009, Toya et al., 2014ほか）。その後の研究で、初老期のMDマウスでは認知力が著名に低下していることも発見した。この研究では若年期の認知能力は正常であったが、これまでの知見から、MDマウスは特に性成熟前期（6－8週齢）にシナプスの脆弱性が顕著であることを報告しており（Takatsuru et al., 2009）、認知機能に関してはさらなる研究の継続が必要であると考えている。そこで本計画では、性成熟前期のMDマウスを様々な環境で飼育し、それに伴う認知機能の変化を研究することで、周産期ストレスが思春期の脳機能およびストレス脆弱性の形成に寄与するメカイズムを解明することを計画した。 本研究の結果、周産期ストレスを負荷した後のマウスを個別に飼育した場合と、集団で飼育した場合とで、その後の学習行動試験（タッチパネルオペラント装置を用いた視覚弁別課題）の結果に差が見られる可能性が示唆された。この原因について精査することを計画したが、研究代表者の異動・科研費申請資格喪失に伴い、研究終了となった。
    周産期ストレスに起因する思春期精神疾患発症メカニズムの解明Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research ...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up
    Date (from‐to) : 2015/08 -2017/03 
    Author : Hanamura Kenji; TAKATSURU YUSUKE
     
    In vivo imaging by using two-photon laser microscopy under deep anesthesia revealed dendritic spine morphology of pyramidal neurons in the cerebral cortex of transgenic mice expressing GFP under the control of Thy1-promoter. Analysis of heterozygotes of knockout mice deficient in drebrin A-specific exon or all drebrin isoforms tended to show some changes in turnover rate of dendritic spines compared with wild-type mice. The amount of NMDA receptors in synaptosomes were detected by western blotting.
    Analysis of activity-dependent dynamics of NMDA receptors in mice with age-dependent synaptic dysfunctionJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid f...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2014/04 -2017/03 
    Author : Takatsuru Yusuke; AMANO Izuki; OBI Kisho; TOBITA Seiji; YOSHIHARA Toshitada
     
    In this study, we observed the role of astrocyte on remodeling for functional compensation in contralateral hemisphere of focal stroke. We found that dopamine is one of the strong candidate for contributing the functional remodeling/recovery after focal stroke. We also found that repetitive application of Aripiprazole, one of the partial agonist for dopamine receptor, enhances the remodeling of neuronal circuit in intact hemisphere after focal stroke. Since the Aripiprazole enhances the activity of astrocyte if it repetitively applied, our study suggested that application of aripiprazole enhances the neuronal remodeling after focal stroke via activation of dopaminergic systems.
    Neuronal remodeling after focal stroke induced by astrocyte stimulationJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)Date (fr...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2013/04 -2017/03 
    Author : Koibuchi Noriyuki; NABWKURA Junichi
     
    This study was designed to examine the effect of the alteration of nuclear receptor-mediated gene expression on brain development. Using in vivo preparation, we found that congenital hypothyroid mouse and rat showed cerebellar ataxia. Electrophysiological study showed that such alteration may be induced by an aberrant synaptic function between parallel fiber and Purkinje cell. Perinatal PCB treatment induced the similar phenotype. Using in vitro preparation, we established the primary culture system of the hippocampus to study the effect of thyroid hormone. In addition, we examined the affect of gadolinium-based contrast agents (GBCA) on thyroid hormone action and found that linear GBCA disrupted thyroid hormone receptor action and thyroid hormone-mediated cerebellar dendritogenesis of Purkinje cell.
    Effects of environmental factors on small lipophilic hormone-mediated development of brain functionJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Sci...See More
  • 酸素感受性錯体プローブの開発による脳虚血評価系の構築
    群馬大学：平成２８年度医理工生命医科学融合医療イノベーション
    Date (from‐to) : 2016/04 -2017/03 
    Author : 髙鶴裕介; 吉原利忠; 飛田成史
  • 脳梗塞後の健常半球神経回路再編成におけるアストロサイトの役割の解明
    （財）武田科学振興財団：2014年度 医学系研究奨励
    Date (from‐to) : 2014/08 -2017/03 
    Author : 髙鶴裕介
  • アストロサイトの世界～脳梗塞後の機能回復～
    日本学術振興会：ひらめきときめきサイエンス
    Date (from‐to) : 2015/04 -2016/03 
    Author : 髙鶴裕介
  • 酸素感受性錯体プローブの開発による脳虚血評価系の構築
    群馬大学：平成２７年度医理工生命医科学融合医療イノベーション
    Date (from‐to) : 2015/04 -2016/03 
    Author : 髙鶴裕介; 吉原利忠; 飛田成史
  • 酸素感受性錯体プローブの開発による脳虚血評価系の構築
    群馬大学：平成２６年度医理工生命医科学融合医療イノベーション
    Date (from‐to) : 2014/04 -2015/03 
    Author : 髙鶴裕介; 吉原利忠; 飛田成史
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    Date (from‐to) : 2011/04 -2013/03 
    Author : 高鶴 裕介
     
    母子乖離操作により慢性ストレスを付加したマウスを成体の時点で研究した結果、以下の知見を得た。 雄の母子乖離マウスにおいて、（１）母子乖離マウスでは体性感覚野における神経活動が亢進しており、それに相関して知覚閾値の低下がみられた。（２）同部位ではグルタミン酸の過剰放出が起こっていた。（３）ホームケージにいるときでもストレスホルモン（コルチコステロン）の分泌が増加していた。（４）急性ストレスの追加負荷により、通常みられるコルチコステロンの一過性上昇が、母子乖離マウスでは消失していた。一方、同時に計測したグルタミン酸の濃度は、母子乖離マウスで顕著に増加していた。（５）急性ストレス負荷後、対照群に比べ一部のグルタミン酸受容体の発現が過剰増加していた。（６）同マウスをin vivo imaging法により生きたまま観察すると、マイクログリアの動態が変化していることが分かった。以上の結果は2報の論文として執筆中である。 また、雌の母子乖離マウスにおいて（１）母子乖離マウスは妊娠・出産に至る割合が低下し、かつ、仔育てを失敗する（育児放棄により仔が死亡する）割合が増加していた。（２）母子乖離マウスを母親にもつ仔では、体重が減少傾向にあり、血中コルチコステロン濃度が有意に増加していた。（３）母子乖離マウスを母親にもつ仔の行動パターンに異常が見られた。（４）（１）の知見は世代間で伝搬する傾向があり、母子乖離マウスの娘や孫でも妊娠・出産率の低下や育児放棄率の増加がみられた。以上の結果は1報の論文として執筆中である。
    ストレスホルモンによる場（神経回路）の変化とマイクログリアの相互作用Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed rese...See More
  • 母子乖離モデルマウスにおけるシナプス不安定化メカニズムの解明
    群馬大学：教育研究社会貢献支援経費（研究助成）
    Date (from‐to) : 2012/04 -2013/03 
    Author : 髙鶴裕介
  • 新研究法・新分野・新研究領域開拓のための研究会（第一回伊香保BSの会）
    包括脳育成支援委員会・研究集会サポートプログラム
    Date (from‐to) : 2011/04 -2012/03 
    Author : 髙鶴裕介
  • 2光子顕微鏡による表皮内Ca動態の可視化の検討
    （株）資生堂：髙鶴裕介共同研究費23-07株式会社資生堂
    Date (from‐to) : 2011/04 -2012/03 
    Author : 髙鶴裕介
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2009 -2012 
    Author : KOIBUCHI Noriyuki; TAKESHITA Akira; TAKATSURU Yusuke; IWASAKI Toshiharu; SIMOKAWA Noriaki
     
    Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.
    Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.Japan Society for the Promotion of Science：Grants-in-Aid for Scientific...See More
  • 2光子顕微鏡による表皮内Ca動態の可視化の検討
    （株）資生堂：髙鶴裕介共同研究費22-15株式会社資生堂
    Date (from‐to) : 2010/04 -2011/03 
    Author : 髙鶴裕介
  • 局所脳梗塞後の機能回復に関わる神経回路再編成のメカニズム
    群馬大学（群馬大学医師会）：基礎医学等研究助成金
    Date (from‐to) : 2010/04 -2011/03 
    Author : 髙鶴裕介
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2009 -2010 
    Author : TAKATSURU Yusuke
     
    Remodeling and/or synapse plasticity is increased at 1^ week after stroke in intact hemisphere. In contrast, recovery of general behavior is delay compared with those in simple somatosensory function. During the remodeling, glutamine, glysine and dopamine seems to be play an important role. Application of haloperidol at 2-4 days after stroke prolongs the recovery.
    Mechanism of remodeling and functional compensation after stroke in intact hemisphereJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists ...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas
    Date (from‐to) : 2006 -2010 
    Author : NABEKURA Junichi; MAEJIMA Takashi; WATANABE Miho; TAKATSURU Yusuke; WATANABE Miho
     
    The neuronal K(+)-Cl(-) cotransporter (KCC2) is a membrane transport protein that extrudes Cl(-) from neurons and helps maintain low intracellular [Cl(-)] and hyperpolarizing GABAergic synaptic potentials. Depolarizing gamma-aminobutyric acid (GABA) responses in neonatal neurons and following various forms of neuronal injury are associated with reduced levels of KCC2 expression. Mutation to the putative tyrosine phosphorylation site within the long intracellular carboxyl terminus of KCC2(Y1087D) or application of the tyrosine kinase inhibitor genistein shifted the GABA reversal potential (E(GABA)) to more depolarized values, indicating reduced KCC2 function. This was associated with a change in the expression pattern of KCC2 from a punctate distribution to a more uniform distribution, suggesting that functional tyrosine-phosphorylated KCC2 forms clusters in restricted membrane domains. A tyrosine phosphatase inhibitor increased the proportion of KCC2 associated with lipid rafts membrane domains. These results indicate that direct tyrosine phosphorylation of KCC2 results in membrane clusters and functional transport activity. Oxidative stress resulted in a rapid dephosphorylation of KCC2 that preceded the decreases in KCC2 protein or mRNA expression. Dephosphorylation of KCC2 is correlated with a reduction of transport activity and a decrease in [Cl-]i, as well as a reduction in KCC2 surface expression. Manipulation of KCC2 tyrosine phosphorylation resulted in altered neuronal viability in response to in vitro oxidative stress. We propose that neuronal stress induces a rapid loss of tyrosine phosphorylation of KCC2 that results in translocation of the protein and functional loss of transport activity.
    Regulation of K-Cl transporter and modal shift of GABA response in development and recovery.Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2007 -2008 
    Author : NABEKURA Junichi; ISHIBASHI Hitoshi; WATANABE Miho; TAKATSURU Yusuke
     
    聴覚中継路である内側台形体核(NMTB)から外側上オリーブ核(LSO)への入力は発達とともにGABAからグリシンへスイッチする。今回、この伝達物質自体のスイッチングの生理学的意義を解明するために、未熟期におけるGABAB受容体の回路機能発達に対する役割を検討した。未熟期には神経終末から放出されるGABAによって終末に存在するGABAB受容体が活性化されるが、発達とともにLSO核からGABAB受容体の発現が消失した。GABAB受容体ノックアウト動物も用いて未熟期のみ発現するGABAB受容体の意義の解明を行った。生後3週目のGABABノックアウトマウスにおいては、NMTB-LSOシナプスにおいて、細胞間に入力様式のばらつきが確認された。この原因はノックアウトマウスではシナプス小胞の伝達放出効率のばらつきに起因することが示唆された。この結果から、幼若期にGABAである生理的な意義として、GABAによるGABAb受容体の活性化、これによる長期的な抑制性性伝達回路の入力の細胞間の均一化に寄与していることが示唆される。
    Functional implication of transmitter switching of inhibitory Circuits.Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)Date (fr...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2007 -2008 
    Author : TAKATSURU Yusuke
     
    2光子励起レーザー顕微鏡を用いたIn vivo imagingの技術を用いることで、障害回復期における、健常側相同部位の神経細胞突起(スパイン)の形態的変化の臨界期を確定することが出来た。また、その前後で機能回復とそれに伴う神経回路変化が想定される実験結果を得ることが出来た。
    In vivo imaging of neuron・glia during the recovery from infarction by using two-photon laser microscopyJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for...See More

Teaching Experience

  • Food and Health
    Toyo University
  • Basic Medicine
    Toyo University
  • Clinical Medicine
    Toyo University

Social Contribution

  • 認知症対応型サービス事業開設者研修
    Date (from-to) : 2020-Today
    Role : Lecturer
    Category : Qualification seminar
  • 認知症介護実践リーダー研修
    Date (from-to) : 2020-Today
    Role : Lecturer
    Category : Qualification seminar
  • 出張講義（認知症との上手な付き合い方)＠きらめき市民大学
    Date (from-to) : 2024/01/25
    Role : Lecturer
    Category : Visiting lecture
  • 出張講義（体を作る食 ～3大栄養素の代謝と相互作用～)＠南浦和高校
    Date (from-to) : 2023/11/09
    Role : Lecturer
    Category : Visiting lecture
  • 出張講義（脳梗塞からの機能回復 ～見えないものを見てみよう～)＠茨城高校
    Date (from-to) : 2023/07/15
    Role : Lecturer
    Category : Visiting lecture
  • 教えて先生
    Date (from-to) : 2012-2018
    Role : Lecturer
    Category : Lecture
  • スーパーサイエンスハイスクール
    Date (from-to) : 2015-2016
    Role : Lecturer
    Category : Visiting lecture
  • ひらめきときめきサイエンス
    Date (from-to) : 2015
    Role : Planner
    Category : Seminar
  • ひらめきときめきサイエンス
    Date (from-to) : 2011-2013
    Role : Planner
    Category : Seminar
  • 世界脳週間
    Date (from-to) : 2012
    Role : Lecturer
    Category : Lecture

Academic Contribution

  • Associate editor (Frontiers in Neuroscience)
    Date (from-to) :2022/04/06-Today
    Role: Review
    Type: Peer review etc
  • 論文査読 42報
    Date (from-to) :2010-2019
    Role: Peer review
    Type: Peer review etc
  • 伊香保BSの会・多分野交流会（5回開催）
    Date (from-to) :2011-2017
    Role: Planning etc
    Type: Academic society etc
  • 第2回GUMI2015（医理工国際シンポジウム）の企画・運営
    Date (from-to) :2015
    Role: Planning etc
    Type: Competition etc
  • FAOPS2015・Japan nightの運営
    Date (from-to) :2015
    Role: Planning etc
    Type: Exhibition

Other link

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