Researchers Database

Shigehiko Ogoh

    Department of Biomedical Engineering Professor
    Research Institute of Industrial Technology Professor
    Course of Biomedical Engineering Professor
    Research Center for Biomedical Engineering Professor
Last Updated :2021/10/15

Researcher Information

Research funding number

  • 80553841

J-Global ID

Research Interests

  • 静的運動   超音波ドップラー法   脳循環   椎骨動脈血流量   生理学   血管抵抗   運動   外頸動脈血流量   循環器   内頸動脈血流量   中心循環   呼吸器   システム制御工学   フィードバックシステム   二酸化炭素濃度   循環調節   高炭酸ガス   高齢者   呼吸調節   CO_2感受性   運動後筋虚血   脳血流量   血圧   自動調節   体力   

Research Areas

  • Life sciences / Physiology
  • Life sciences / Clinical pharmacy
  • Life sciences / Physiology
  • Life sciences / Nutrition and health science
  • Life sciences / Sports science

Academic & Professional Experience

  • 2021/01 - Today  ちふれASエルフェン(女子サッカーWEリーグ所属)埼玉マリU18フィジカル&コンディショニングコーチ
  • 2020/12 - Today  Frontiers in Physiology編集委員(Associate Editor)
  • 2019/02 - Today  University of QueenslandVisiting Researcher
  • 2019 - Today  Journal of Clinical Medicine (Vascular Medicine)Editor
  • 2019 - Today  Exercise and Sport Sciences ReviewsEditor
  • 2018 - Today  PLoS OneEditor
  • 2017 - Today  産業総合研究所客員研究員
  • 2017 - Today  University of South WalesVisiting Professor
  • 2015 - Today  Experimental Physiology (The Physiological Society, UK)Editor
  • 2013 - Today  Biomedical Research International (Physiology)Editor
  • 2010 - Today  Journal of Physiological Sciences (The Physiological Society, Japan)Editor
  • 2009/04 - Today  Toyo University, JapanDepartment of Biomedical EngineeringProfessor
  • 2009 - Today  Centre national d'études spatiales(CNES)Visiting Researcher
  • 2012 - 2017  Agence spatiale européenne(ESA)Visiting Researcher
  • 2009 - 2016  Japan Women's College of Physical Education客員研究員
  • 2012 - 2013  International Journal of Clinical & Medical ImagingEditor
  • 1999/04 - 2009/03  University of North Texas Health Science Center, Fort Worth, Texas, USA.Department of Integrative physiology

Education

  • 1994/04 - 1999/03  Kyoto University Graduate School  Human and Environmental Studies  Graduate School
  • 1994/04 - 1999/03  京都大学大学院

Association Memberships

  • THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE   PHYSIOLOGICAL SOCIETY OF JAPAN   The physiological Society   The American College of Sports Medicine   The American Physiological Society   

Published Papers

Books etc

MISC

Awards & Honors

  • 2014 American College of Sports Medicine (ACSM) Fellow
     
    受賞者: Shigehiko Ogoh
  • 2012 The Japanese Society of Physical Fitness and Sports Medicine & European College of Sports Science Research Travel Award
     
    受賞者: Shigehiko Ogoh
  • 2006 American College of Sports Medicine (ACSM) Visiting Scholar Award
     
    受賞者: Shigehiko Ogoh
  • 2006 The American Physiological Society Neural Control and Autonomic Regulation (NCAR) Research Recognition Award
     
    受賞者: Shigehiko Ogoh
  • 2005 American College of Sports Medicine (ACSM) New Investigator Award
     
    受賞者: Shigehiko Ogoh
  • 2004 American Heart Associate (AHA) Research Award (Texas Affiliate, Beginning grants-in-aid)
     
    受賞者: Shigehiko Ogoh
  • 2004 Texas Chapter American College of Sports Medicine (ACSM) Research Presentation Award
     
    受賞者: Shigehiko Ogoh
  • 2000 UNTHSC Post-doctoral Travel Award
     
    受賞者: Shigehiko Ogoh
  • The American Physiological Society Career Enhancement Award
     
    受賞者: Shigehiko Ogoh

Research Grants & Projects

  • Arterial blood pressure regulation during exercise by muscle pump and cardiopulmonary baroreflex
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2019/04 -2022/03 
    Author : 片山 敬章; 石田 浩司; 小河 繁彦
  • 運動昇圧応答の個人差が脳循環調節機能に及ぼす影響の検証
    井上記念研究助成:
    Date (from‐to) : 2021 -2022 
    Author : 小河繁彦
  • サッカーの運動特性に対するフィジカル評価:女子プロサッカー下部組織ユース選手において
    デサントスポーツ財団研究助成:
    Date (from‐to) : 2021 -2022 
    Author : 小河繁彦
  • サッカーの運動特性に対するフィジカル評価:女子プロサッカー下部組織ユース選手において
    工業技術研究所プロジェクト:
    Date (from‐to) : 2021 -2022 
    Author : 小河繁彦
  • 運動時の血圧調節に筋ポンプおよび心肺圧受容器が果たす役割の解明
    文部科学省 科学研究費補助金(基盤研究B):
    Date (from‐to) : 1999 -2022 
    Author : 片山敬章
  • Paradox of effect of exercise on cognitive function and cardiovascular system
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2018/04 -2021/03 
    Author : 小河 繁彦; 橋本 健志; 家光 素行
     
    我々の研究グループにおいて、運動習慣が脳認知症発症を予防(Tarumi et al. 2017)、また一過性の運動においても認知機能を高めることを報告した(Ogoh et al. 2014)。特に近年、運動は認知症発症予防の有効な手段として臨床研究分野において注目されており、重要な研究対象となっている。本申請研究では、この運動による認知機能改善のメカニズムに関するパラドックッスを明らかにすることを目的としている。平成30年度は、初年度であり、特に脳血流と認知機能との関連を明らかにするための実験を行ってきた。我々は、高強度インターバルエクササイズ(HIIE)は脳実行機能(EF)を改善することを報告したが(Tsukamoto et al. 2016)、この時の脳血流、脳乳酸摂取量、脳由来神経栄養因子(BDNF)の変化と認知機能改善との関連性を確かめるため実験を行った。我々は、高強度運動時脳血流が低下していることから(Ogoh et al. 2005)認知機能の改善は、脳乳酸摂取に関連すると仮説を立てた。脳乳酸摂取量を変化させる為、14名の健康な男性被験者は、60分の休憩を挟んで、2セットのHIIEを行った。血液サンプルを、右頸静脈および上腕動脈から得て、乳酸、グルコース、酸素、およびBDNF動静脈較差を算出した。また、実行機能(EF)は、カラーワードStroopタスクによって評価した。1回目のHIIEでは運動後40分間EFを改善したが、2回目HIIEでのEFの改善は運動直後のみであった。HIIE後のEFは特に脳の乳酸代謝の減少に関連した。これらの結果は、脳機能は、乳酸シャトルメカニズムの例として全身代謝に関連していることを示唆した。これらの結果は、FASEB J. (2018:1417-1427)で発表した。
  • 高次脳機能の維持・改善に重要なヒト脳内代謝機序の解明と運動・栄養処方基盤の創出
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2018/04 -2021/03 
    Author : 橋本 健志; 小河 繁彦; 家光 素行
     
    運動による認知機能亢進の作用機序は未解明な部分が多く、具体的方略は不明瞭なままである。本研究では、中高齢者を対象とした運動処方基盤を構築し、且つ、好適な栄養処方を付加できるよう、脳内エネルギー代謝が認知機能亢進に及ぼす影響や、運動・栄養処方による脳機能応答の詳細をヒトにおいて生理・生化学的に明らかにし、脳機能亢進や認知症予防に極めて重要かつ独創的な機序の解明と、適切な実践的応用方略策定の学術的基盤を創出することを目的とする。本研究では、上腕動脈と頸静脈にカテーテルを挿入し、乳酸、グルコース、酸素や神経伝達物質、脳由来神経栄養因子などの脳を介した動静脈較差(Across the Brain)を算出することにより、運動・栄養処方に対するヒト脳内代謝動態を測定し、認知機能との関連性を検証するという他に類を見ない研究アプローチを推進するものである。高次脳機能の維持・改善に重要な生理的ストレスに関する学術的基盤創出に貢献し、認知機能向上に適した運動・栄養処方の具体的方略の策定に寄与し得るものと考えている。 本年度は、高強度間欠的運動前後でのヒト脳内代謝をメタボローム解析によって網羅的に解析する実験を推進した。動静脈較差(Across the Brain)を算出することにより、これまで認識されていなかった代謝動態が明らかとなった(論文投稿準備中)。 また、運動と脳循環応答との関係性において、高強度間欠的運動では、脳自己調節機能は保持されていることを明らかにした(Tsukamoto et al., MSSE 2018)。 一方、日本人を対象に、年齢と認知実行機能との関係性を整理するとともに、中高齢者に対する一定期間のレジスタンス運動が脳機能に与える効果についても検証した(論文投稿準備中)。
  • 多階層的研究によるアスリートサポートから高齢者ヘルスサポート技術への展開 ~社会実装に向けての研究組織連携の構築~
    東洋大学重点研究推進プログラム研究費:
    Date (from‐to) : 2020 -2021
  • 運動の認知機能に及ぼす効果におけるパラドックスの解明 研究課題
    文部科学省 科学研究費補助金(基盤研究B):
    Date (from‐to) : 2018 -2021 
    Author : 小河 繁彦
  • 高次脳機能の維持・改善に重要なヒト脳内代謝機序の解明と運動・栄養処方基盤の創出
    文部科学省 科学研究費補助金(基盤研究B):
    Date (from‐to) : 2018 -2021 
    Author : 橋本 健志
  • 多階層的研究によるアスリートサポートから高齢者ヘルスサポート技術への展開
    私立大学研究ブランディング事業 <タイプB> (文部科学省, Japan):
    Date (from‐to) : 2018 -2020
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2016/04 -2019/03 
    Author : Yoshitake Yasuhide
     
    The 1st study examined corticospinal excitability during unilateral force-matching tasks of different difficulty. Single pulse TMS was applied to the hemispheres of seventeen young male during force matching tasks with easy (EASY) and difficult (DIFF) task difficulty. MEPs were significantly larger (P < 0.05) during DIFF than EASY. These results indicate that greater task difficulty increases corticospinal excitability of both contralateral and ipsilateral hemispheres. The 2nd study tested the effect of the exercise training with task difficulty on muscle and cognitive function. After 3 month-exercise training, exercise training with task difficulty enhanced some cognitive function scores greater than traditional exercise training while exercise training volume evaluated by surface EMG was comparable between training. The results indicated that exercise with task difficulty should be better way to enhance muscle and cognitive function than traditional training regimen.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2016/04 -2019/03 
    Author : YAMATO Yosuke
     
    This study aimed to clarify whether the effect of stretching exercise on arterial stiffness. Healthy young men were performed whole-body or one-legged static stretching exercise. The brachial-ankle pulse wave velocity and femoral-ankle pulse wave velocity were significantly reduced relative to baseline and 15 and 30 min after whole-body stretching exercise. The femoral-ankle pulse wave velocity in the stretched leg was significantly decreased from baseline to immediately and 15 min after one-legged stretching exercise. Additionally, posterior tibial artery blood flow and shear rate in the stretched leg were significantly increased from baseline to relaxation period. These results suggest that the increased in blood flow and/or shear rate by stretching exercise may be associated with reduction of arterial stiffness in young men.
  • 高強度運動による活性酸素(ROS)産生が循環機能に及ぼす影響
    デサントスポーツ財団研究助成:
    Date (from‐to) : 2018 -2019 
    Author : 小河繁彦
  • 高齢者の複合的行動能力を特異的に鍛えるトレーニング法の開発
    文部科学省 科学研究費補助金(基盤研究B):
    Date (from‐to) : 2016 -2019 
    Author : 吉武 康栄
  • 動脈硬化の予防・改善を目的としたストレッチ運動プログラムの開発
    文部科学省 科学研究費補助金(基盤研究C):
    Date (from‐to) : 2016 -2019 
    Author : 大和洋輔
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2015/04 -2018/03 
    Author : Ogoh Shigehiko
     
    Reduction in cerebral blood flow may increase a risk of developing cerebral diseases such as cerebral infarction (Han et al. JCBFM 2007) and it may be associated with the onset of dementia (Franceschi Dementia et al. 1995) . It has been suggested that chronic exercise improves the regulation of cerebral circulation and consequently reduces a risk of developing brain diseases. The purpose of this project was to identify the physiological mechanism or its importance of the vascular regulation in the different cerebral arteries. In this project, we found important information regarding physiological mechanism of cerebral artery and arteriovenous blood flow distribution to each physiological stimulus in this related researches, and have published 42 papers in English physiological journals for our results in these researches.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
    Date (from‐to) : 2015/04 -2017/03 
    Author : Hashimoto Takeshi
     
    This study was conducted to determine the relationship between brain metabolism and brain function (e.g., executive function) during exercise in human. It is suggested that alterations in exercise-induced systemic lactate levels affect brain lactate uptake, thereby influencing executive function.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2014/04 -2017/03 
    Author : SATO Kohei
     
    Recent studies have suggested that vertebral artery (VA) hypoplasia is a predisposing factor for posterior cerebral stroke. We examined whether anatomical vertebrobasilar ischemia, i.e., unilateral VA hypoplasia and insufficiency, impairs dynamic blood flow regulation. Twenty-eight female subjects were divided into three groups by defined criteria: 1) unilateral VA hypoplasia (N = 8), 2) VA insufficiency (N = 6), and 3) control (N = 14). We evaluated left, right, and net VA blood flows by ultrasonography during hypercapnia, normocapnia, and hypocapnia to evaluate VA CO2 reactivity. In this tudy, VA hypoplasia reduced CO2 reactivity, although non-hypoplastic VA may compensate this regulatory limitation. In subjects with VA insufficiency, lowered CO2 reactivity at the both VA could not preserve normal net VA CO2 reactivity. Our findings provide important information regarding anatomical risk for stroke and ischemia in posterior cerebral circulation.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2013/04 -2017/03 
    Author : Sadamoto Tomoko; NATSUI HIROAKI; SATO KOHEI; OOUE ANNA; Otsuki Aki; YNEYA MARINA
     
    Circulating estrogen is believed to a dilator of cerebral vessels, but impact of female hormones on the cerebrovascular regulation is not fully understood. In young healthy females, the cerebrovascular CO2 reactivity, a potent mediator of cerebral flow regulation during exercise, was measured in the internal carotid artery (ICA) and the vertebral artery (VA) during early follicular, late follicular, and mid luteal phases of menstrual cycle. The CO2 reactivity in females was similar to that observed in males and unchanged across three phases of menstrual cycle in both ICA and VA, suggesting that female hormones are not determining factors for the cerebrovascular CO2 reactivity.
  • 運動時の脳血流調節における性差の探究
    文部科学省 科学研究費補助金(基盤研究B):
    Date (from‐to) : 2013 -2017 
    Author : 定本 朋子
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
    Date (from‐to) : 2013/04 -2016/03 
    Author : Shigehiko Ogoh; SATO Kohei; TANAKA Naoki
     
    Spatially resolved near-infrared spectroscopy (NIRS) is used widely to measurement of regional cerebral oxygenation, but the NIRS signal is influenced by changes in extra cranial blood flow. We estimated an accurate cerebral oxygenation during exercise and cognitive task using new algorithm which eliminates the influence of the extra cranial blood flow on the NIRS signals. Our findings suggest the possibility that the new algorithm excludes the influence of skin blood flow on the NIRS-determined O2Hb even during condition with increased cerebral oxygenation.
  • 運動時ヒト脳代謝動態と認知機能亢進の生理的機序の解明
    文部科学省 科学研究費補助金(挑戦的萌芽):
    Date (from‐to) : 2015 -2016 
    Author : 橋本 健志
  • 椎骨動脈の動的血流調節:低形成の影響とトレーニングの効果を探る
    文部科学省 科学研究費補助金(基盤研究C):
    Date (from‐to) : 2014 -2016 
    Author : 佐藤 耕平
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2012/04 -2015/03 
    Author : OGOH Shigehiko; MIYAMOTO Tadayoshi; SUGAWARA Jun; KATAYAMA Keisho
     
    In our country, it has been reported that 10% of elderly who is more than 65 years old, is Dementia. Recently, epidemiological studies suggest that chronic exercise training or exercise habit decreases a risk of cerebral disease including dementia. Therefore, for many researchers it is worthy to note the relationship between cerebral disease and exercise habit. However, cerebral circulation has some complicated physiological mechanisms, thus, we do not have any physiological evidences of the effect of chronic exercise training on preventing cerebral disease. In the present research project, as a fundamental study in this research area, we demonstrated new findings about the adaptation of cerebral blood flow regulation system related to cerebral disease to chronic exercise. In addition, we found the relationship between systemic circulatory or respiratory regulation system and cerebral circulatory system in this project.
  • The effect of changes in cerebral blood flow cognitive function and cerebral blood flow
    デサントスポーツ財団研究助成:
    Date (from‐to) : 2014 -2015 
    Author : Shigehiko Ogoh
  • Cardiovascular deconditioning; Otolith; Baroreflex; neurovestibular; artificial gravity
    International Research Staff Exchange Scheme(FP7-PEOPLE-2012-IRSES):
    Date (from‐to) : 2012 -2015 
    Author : Pierre Denise
  • Relationship between cardiovascular deconditioning observed after bed-rest and alterations in otolith influences on vascular system
    European Science Foundation AO-2009-BR-0913 (ESA, Europe):
    Date (from‐to) : 2009 -2015 
    Author : Pierre Denise
  • 脳科学を基盤としたストレスの可視化によるヘルスサポートシステムの開発
    私立大学戦略的研究基盤形成支援事業 (文部科学省, Japan):
    Date (from‐to) : 2010 -2014
  • トップアスリートのコンディショニングを探る~効果的トレーニングから東洋大学駅伝部パフォーマンス向上を目指す~
    東洋大学特別研究費:
    Date (from‐to) : 2012 -2013 
    Author : 小河繁彦
  • Effect of aerobic fitness on cerebral blood flow and cerebral autoregulation
    デサントスポーツ財団研究助成:
    Date (from‐to) : 2012 -2013 
    Author : Shigehiko Ogoh
  • 脳循環系疾患発症のメカニズムを探る~呼吸性疾患との関連~
    東洋大学特別研究費:
    Date (from‐to) : 2011 -2012 
    Author : 小河繁彦
  • 運動後の血圧低下作用の差異を生む要因を探る-血圧管理のための効果的な運動プログラムの構築を目指して
    中富健康科学振興財団研究助成金:中富健康科学振興財団研究助成金
    Date (from‐to) : 2011 -2012 
    Author : 菅原 順
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2010 -2012 
    Author : MIYAMOTO Tadayoshi; OGOH Shigehiko; NAKAHARA Hidehiro
     
    Although previous findings indicate that central blood volume (CBV) shift influences the respiratory regulation, the major regulatory mechanisms in the respiratory chemoreflex system which determine the operating arterial partial pressure of CO2 and minute ventilation responses to changes in CBV remain unclear. Using respiratory equilibrium diagram analysis, we evaluated the effect of CBV shift on the respiratory chemoreflex system divided into two subsystems: a controller (controlling system) and a plant (controlled system). Our findings first provide that CBV shift are related to the alteration in the properties of both controller and plant subsystems, and thus alter the operation mechanism of respiratory regulation under CBV shift. The equilibrium diagram analysis clearly indicates that resetting of the controller, rather than the plant, contributes predominantly to shift in the operating point under CBV shift.The respiratory controller resetting and/or plant dysfunction induced by CBV shift may be contributing to ventilatory abnormalities in CHF.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2010 -2012 
    Author : SADAMOTO Tomoko; OGO Shigehiko; SATO Kouhei; OOUE Anna
     
    Blood supply to the brain originates from two roots, the internal carotid arteries (ICA) and the vertebral arteries (VA). ICA provides blood to cerebral cortex forming the anterior cerebral circulation, while VA supplies blood to occipital cortex, cerebellum, and brainstem forming the posterior cerebral circulation. Although previous studies assumed that the cerebral blood flow in two roots were similar during exercise, the present study demonstrated that there are different responses between two roots indicating regional differences in the brain circulation. Further, difference in arterial CO_2 reactivity found to be a mediator for the regional difference in the brain circulation.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2009 -2011 
    Author : SATO Kohei; SADAMOTO Tomoko; OOUE Anna; HIRASAWA Ai; OGOH Shigehiko
     
    The aim of this study was to determine whether the association between the resting cerebral blood flow and physical fitness in elderly women. The main finding of the present study was that total fitness level in elderly women was significantly correlated with resting cerebral blood flow. These finding suggest that the age-related reduction in cerebral blood flow is attenuated by maintain the high physical fitness level.
  • Consistently and reliably measuring muscle or skin sympathetic nerve activity (SNA) in the leg and arm during dynamic exercise
    American College of Sports Medicine (ACSM, USA) Visiting Scholar Award:
    Date (from‐to) : 2006 -2007 
    Author : Shigehiko Ogoh
  • Carotid baroreflex control of muscle sympathetic nerve activity (MSNA) during dynamic exercise
    The American Physiological Society (APS, USA) Career Enhancement Award:
    Date (from‐to) : 2006 -2007 
    Author : Shigehiko Ogoh
  • Cardiopulmonary baroreflex control of blood pressure during exercise
    America Heart Association (AHA, USA):
    Date (from‐to) : 2004 -2007 
    Author : Shigehiko Ogoh
  • Arterial Baroreflex control of blood pressure: Exercise.(renewal)
    National institute health (NIH, USA)/NHLBI:
    Date (from‐to) : 2003 -2007 
    Author : Peter Raven
  • Arterial Baroreflex control of blood pressure: Exercise.
    National institute health (NIH, USA)/NHLBI:
    Date (from‐to) : 1999 -2003 
    Author : Peter Raven