Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation, Jun Sugawara, Christopher K. Willie, Taiki Miyazawa, Hidehiko Komine, Philip N. Ainsle, Shigehiko Ogoh, Artery Research, 6, 2012 09 01 , Stiffening of central conduit arteries -areas where the mechanoreceptors are embedded (e.g., ascending aorta and carotid artery) - is considered to be associated with the impaired baroreflex control in response to hypotensive stress. Arterial stiffness is modulated by vascular tone transiently and dynamically, however, it is unknown whether a transient change in the carotid artery stiffness influences the cardiac baroreflex response to a rapid hypotension. We measured (n = 11) carotid arterial stiffness (via concurrent applanation tonometory and ultrasound imaging) at supine rest and during 20-degree head-up tilt (HUT). To evaluate the cardiac baroreflex response, acute hypotension was evoked by releasing bilateral thigh cuffs after 3 min of suprasystolic resting ischemia at each posture; cardiac baroreflex sensitivity (e.g., change in heart rate for a given change in mean arterial pressure, ΔHR/ΔMAP) and latency (e.g., the time to peak HR response) was estimated. Carotid β-stiffness index, a measure of arterial stiffness, was reduced by 14% during HUT (P < 0.05 vs. supine position). Although cardiac baroreflex responses were unaltered, the within-group biological variability in the cardiac baroreflex sensitivity and latency from the supine to HUT was correlated with the corresponding changes in carotid arterial stiffness (r = 0.66 and r = 0.64, respectively, both P < 0.05). These findings suggest that a transient change in carotid arterial stiffness, at least in part, influences changes in the cardiac baroreflex response to a rapid hypotension. © 2012 Association for Research into Arterial Structure and Physiology.
Effect of Aerobic Fitness on Cerebral Blood Flow and Cerebral Autoregulation, 小河 繁彦, デサントスポーツ科学, 33, 2012 06
1036 Measurements of th arterial baroreflex function during exercise, OGOH Shigehiko, バイオエンジニアリング講演会講演論文集, 2009, 2010 01 08
The bio-signal analysis of cardiovascular response in humans, Shigehiko OGOH, Industrial technology, (32) 40 - 43, 2010
Response to letter by Prakash, Shigehiko Ogoh, Stroke, 39, 2008 11 01
Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow , Shigehiko Ogoh, Journal of Applied Physiology, 105, 2008 10 01
Calcium-supplementation-and Exercise-induced Alterations in Bone and Mitochondria of Skeletal Muscle Fibers in Rats, SENGE Hiroyuki, YAMASAKI Sakiya, OKAMOTO Hiroshi, OGOH Shigehiko, TAGUCHI Sadayoshi, Nippon Eiyo Shokuryo Gakkaishi, 56, (5) 297 - 305, 2003 10 10 , The purpose of this study was to investigate the effects of calcium (Ca) supplementation and prolonged exercise on bone strength and the mitochondrial volume density (MVD) of skeletal muscle fibers in young-adult rats. Thirty-six female rats were divided into three calcium-altered groups (low, 0.02%-LCa; medium, 0.74%-MCa; high, 2.24% wt/wt-HCa), which were further subdivided into the no-exercise (NEx) and exercise (Ex) groups. The Ex groups performed running exercise at a speed of 10m/min for 90-180min/ day, for six weeks. Bone strength in the LCa groups significantly decreased by 16.3-23.4% compared with the MCa groups. However, the rate of reduction in bone strength increased by 43.3% in response to running exercise without any decrease in serum Ca2+ concentration compared with the reduction rate between the NEx groups (LCa-NEx vs MCa-NEx) and the Ex groups (LCa-Ex vs MCa-Ex). Exercise training induced a significant increase in MVD in the soleus muscle cells of all Ex groups. The MVDs of both the slow-twitch oxidative and fast-twitch oxidative glycolytic fibers in the soleus muscle of the NEx groups were not influenced by dietary calcium content, but MVD for the Ex groups further increased significantly with increasing dietary calcium content (HCa>MCa>LCa). These results suggest that a low-calcium diet impairs metabolism in both skeletal muscle and bone tissues. The HCa diet along with exercise training further upregulated skeletal muscle and bone metabolism, whereas the LCa diet inhibited it to induce a training effect.
Adaptation in Properties of Skeletal Muscle to Coronary Artery Occlusion/Reperfusion in Rats, OGOH Shigehiko, HIRAI Taku, NOHARA Ryuuji, TAGUCHI Sadayoshi, 64, (10) 225 - 236, 2002 10 01
6.A histochemical study of skeletal muscle in patients with heart failure., OGOH SHIGEHIKO, TAGUCHI SADAYOSHI, NOHARA RYUJI, Japanese Journal of Physical Fitness and Sports Medicine, 46, 1997 06 01
2.Effect of X-ray irradiation on oxidative and glycolytic enzyme activities in single muscle fibers in rats., OKAMOTO HIROSHI, OGOH SHIGEHIKO, YAMASAKI SAKIYA, TAGUCHI SADAYOSHI, Japanese Journal of Physical Fitness and Sports Medicine, 45, 1996 06 01
3.Differences in SDH activity of superficial and deep regions in single muscle fibers in stroke-prone spontaneously hypertensive rats., OGOH SHIGEHIKO, YAMASAKI SAKIYA, OKAMOTO HIROSHI, TAGUCHI SADAYOSHI, Japanese Journal of Physical Fitness and Sports Medicine, 45, 1996 06 01
14.Epidemiologic Study on the Risk Factors of Diabetes Complications., YAMASAKI SAKIYA, OKAMOTO HIROSHI, OGOH SHIGEHIKO, TAGUCHI SADAYOSHI, Japanese Journal of Physical Fitness and Sports Medicine, 45, 1996 06 01
13.The prediction of 5/S1 compression force during lifting., Ogo Shigehiko, Ishii Kihachi, Japanese Journal of Physical Fitness and Sports Medicine, 42, (2) 233 - 234, 1993 04 01
Intrathoracic Pressure During Lifting Motion., 小河 繁彦, 宮側 敏明, 渡辺 一志, 河端 隆志, 西村 直記, 筒井 るみ子, 前田 如矢, 大阪市立大学保健体育学研究紀要, 29, 1993
Intrathoracic Pressure During Lifting Motion., Ogo Shigeyuki, Miyagawa Toshiaki, Watanabe Hitoshi, Annals of physical education, 29, 1993
一過性の局所的なストレッチ運動が動脈硬化リスクに及ぼす影響, 大和洋輔, 大和洋輔, 長谷川夏輝, 藤江隼平, 小河繁彦, 家光素行, 日本理学療法学術大会(Web), 51st, 2016
Awards & Honors
- 2014 , American College of Sports Medicine (ACSM), Fellow
- 2012 , The Japanese Society of Physical Fitness and Sports Medicine & European College of Sports Science, Research Travel Award
- 2006 , American College of Sports Medicine (ACSM), Visiting Scholar Award
- 2006 , The American Physiological Society, Neural Control and Autonomic Regulation (NCAR) Research Recognition Award
- 2005 , American College of Sports Medicine (ACSM), New Investigator Award
- 2004 , American Heart Associate (AHA) , Research Award (Texas Affiliate, Beginning grants-in-aid)
- 2004 , Texas Chapter American College of Sports Medicine (ACSM) , Research Presentation Award
- 2000 , UNTHSC , Post-doctoral Travel Award
- The American Physiological Society, Career Enhancement Award
Research Grants & Projects
- CEREBRAL BLOOD FLOW REGULATION DURING EXERCISE IN TWO ROOTS OF BRAIN ARTERY, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), Tomoko SADAMOTO, Blood supply to the brain originates from two roots, the internal carotid arteries (ICA) and the vertebral arteries (VA). ICA provides blood to cerebral cortex forming the anterior cerebral circulation, while VA supplies blood to occipital cortex, cerebellum, and brainstem forming the posterior cerebral circulation. Although previous studies assumed that the cerebral blood flow in two roots were similar during exercise, the present study demonstrated that there are different responses between two roots indicating regional differences in the brain circulation. Further, difference in arterial CO_2 reactivity found to be a mediator for the regional difference in the brain circulation.
- Effect of Changes in Central Hemodynamics on the RespiratoryChemorelfex Feedback System Controlling Ventilation in Humans., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), Tadayoshi MIYAMOTO, Although previous findings indicate that central blood volume (CBV) shift influences the respiratory regulation, the major regulatory mechanisms in the respiratory chemoreflex system which determine the operating arterial partial pressure of CO2 and minute ventilation responses to changes in CBV remain unclear. Using respiratory equilibrium diagram analysis, we evaluated the effect of CBV shift on the respiratory chemoreflex system divided into two subsystems: a controller (controlling system) and a plant (controlled system). Our findings first provide that CBV shift are related to the alteration in the properties of both controller and plant subsystems, and thus alter the operation mechanism of respiratory regulation under CBV shift. The equilibrium diagram analysis clearly indicates that resetting of the controller, rather than the plant, contributes predominantly to shift in the operating point under CBV shift.The respiratory controller resetting and/or plant dysfunction induced by CBV shift may be contributing to ventilatory abnormalities in CHF.
- Changes of cerebral blood flow in elderly women during normal aging, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(若手研究(B)), Kohei SATO, The aim of this study was to determine whether the association between the resting cerebral blood flow and physical fitness in elderly women. The main finding of the present study was that total fitness level in elderly women was significantly correlated with resting cerebral blood flow. These finding suggest that the age-related reduction in cerebral blood flow is attenuated by maintain the high physical fitness level.