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Hisao Morimoto

    Department of Mechanical Engineering　Professor
    Bio-Nano Electronics Research Center　Researcher
    Professor
    Course of Advanced Mechatronics Systems　Professor
Last Updated :2025/09/13

Researcher Information

Research funding number

  • 00385957

J-Global ID

Research Interests

  • 複雑流体   バイオ・ナノ融合科学技術   ソフトマター科学   

Research Areas

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Thermal engineering

Academic & Professional Experience

  • 2014/04 - Today  Toyo UniversityFaculty of Science and Engineering教授
  • 2009/04 - 2014/03  Toyo UniversityFaculty of Science and Engineering准教授
  • 2007/04 - 2009/03  Toyo University准教授

Education

  • 1995/04 - 1998/03  東洋大学大学院・工学研究科・機械工学専攻・博士後期課程
  • 1993/04 - 1995/03  東洋大学大学院・工学研究科・機械工学専攻・博士前期課程
  • 1989/04 - 1993/03  東洋大学・工学部・機械工学科

Published Papers

Conference Activities & Talks

  • Synthesis of flower-shaped magnetic particles with ferrocene-ethanol solution and their characterization  [Not invited]
    K. Hiratsuka; S. Kurosu; T. Maekawa; H. Morimoto
    The 13th International Conference on Nanostructures, Nanomaterials and Nanoengineering (ICNNN 2024)  2024/11
  • Synthesis of carbon nano-structures composed of fullerene molecules and (6,6) carbon nanobelts via self-assembly  [Not invited]
    S. Kurosu; H. Morimoto; T. Maekawa
    The 13th International Conference on Nanostructures, Nanomaterials and Nanoengineering (ICNNN 2024)  2024/11
  • Development of a PCR method utilizing the photothermal effect of magnetic carbon nanoparticles  [Not invited]
    Y. Oyoshi; M. Suzuki; T. Maekawa; H. Morimoto
    21st International Symposium on Applied Electromagnetics and Mechanics (ISEM 2023)  2023/11
  • Heat generation efficiency of non-spherical magnetic particles synthesized with a supercritical fluid  [Not invited]
    K. Hiratsuka; M. Suzuki; T. Maekawa; H. Morimoto
    21st International Symposium on Applied Electromagnetics and Mechanics (ISEM 2023)  2023/11
  • Enzymatic activity and thermostability of α-amylase used as a cross-linker for the creation of ferromagnetic nanoparticle clusters  [Not invited]
    M. Suzuki; T. Mizuki; T. Maekawa; H. Morimoto
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Immobilization of α-amylase on ferromagnetic colloidal particles and its enzymatic activity under an ac/dc combined magnetic field  [Not invited]
    M. Karube; M. Suzuki; T. Mizuki; T. Maekawa; H. Morimoto
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Two-dimensional percolation in a thin magnetorheological fluid layer induced by an external dc magnetic field
    Y. Hamada; T. Ukai; H. Morimoto
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Active control of cluster patterns formed by magnetic particles in a fluctuating magnetic field  [Not invited]
    A. Ben Salah; T. Ukai; S. Kurosu; H. Morimoto; T. Maekawa
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Controlled pattern formation consisting of fullerene on a substrate via the coffee-ring effect  [Not invited]
    S. Kurosu; H. Morimoto; K. Takahashi; T. Maekawa
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Clusters formed by superparamagnetic colloidal particles in a thin magnetorheological fluid layer induced by a dc magnetic field  [Not invited]
    T. Ukai; Y. Hamada; T. Maekawa; H. Morimoto
    An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)  2019/11
  • Activation of enzymes utilizing magnetic particles  [Invited]
    H. Morimoto
    Workshop “New Opportunities for Interdisciplinary Research in BIO-NANO-SCIENCE”, Politehnica University of Timisoara  2018/09
  • Cluster formation and enzymatic activity of enzyme/ferromagnetic particle hybrids under an ac/dc combined magnetic field  [Not invited]
    M. Karube; M. Suzuki; T. Mizuki; T. Ukai; T. Maekawa; H. Morimoto
    13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)  2018/09
  • PCR utilizing the photothermal effect of carbon-encapsulated iron nanoparticles  [Not invited]
    T. Kawamata; M. Suzuki; T. Mizuki; T. Maekawa; H. Morimoto
    13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)  2018/09
  • Nanostructures composed of enzyme and ferromagnetic nanoparticles, and their enzymatic activity under external magnetic fields  [Not invited]
    M. Suzuki; T. Mizuki; T. Maekawa; H. Morimoto
    13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)  2018/09
  • Formation of concentric patterns composed of fullerene nano-fibres via convective self-assembly  [Not invited]
    S. Kurosu; H. Morimoto; G. Takase; T. Masuda; T. Maekawa
    13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)  2018/09
  • Structures formed via self-assembly in a superparamagnetic colloidal suspension subjected to an external magnetic field  [Not invited]
    T. Ukai; Y. Hamada; T. Maekawa; H. Morimoto
    13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)  2018/09
  • Formation of concentric patterns composed of fullerene nano-fibres via convective self-assembly  [Not invited]
    S. Kurosu; H. Morimoto; G. Takase; T. Masuda; T. Maekawa
    12th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2017)  2017/09
  • Synthesis of magnetic nano crystals via pyrolysis in ethanol  [Not invited]
    Y. Ishido; Y. Nakajima; H. Morimoto; T. Maekawa
    12th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2017)  2017/09
  • Patterns formed by magnetic particles in combined dc and ac magnetic fields  [Not invited]
    A. Ben Salah; Y. Nagaoka; T. Ukai; H. Morimoto; T. Maekawa
    12th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2017)  2017/09
  • Activity of an enzyme immobilized on ferromagnetic particles under an ac/dc combined magnetic field  [Not invited]
    M. Karube; M. Suzuki; T. Mizuki; T. Maekawa; H. Morimoto
    12th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2017)  2017/09
  • Efficient DNA ligation using DNA ligase immobilized on ferromagnetic particles  [Not invited]
    M. Suzuki; H. Hayashi; T. Mizuki; T. Maekawa; H. Morimoto
    10th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2015)  2015/09
  • Production of invert sugar using invertase immobilized on magnetic particles  [Not invited]
    M. Tateno; M. Suzuki; T. Mizuki; H. Morimoto
    10th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2015)  2015/09
  • Hyperthermia treatment of cancer cells using multi-functional iron-containing carbon nanotubes  [Not invited]
    Y. Nagaoka; N. Dobashi; T. Okada; S. Iwai; H. Morimoto; F. Dillon; N. Grobert; T. Maekawa
    10th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2015)  2015/09
  • Fabrication of micrometre sized magnetic discs of circular and triangular shapes  [Not invited]
    Y. Nagaoka; S. Aoki; T. Ukai; H. Morimoto; T. Maekawa
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Promotion of DNA ligation utilizing heat dissipation from ferromagnetic particles subjected to an ac magnetic field  [Not invited]
    H. Hayashi; M. Suzuki; T. Mizuki; H. Morimoto
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Activity of invertase immobilized on magnetic particles under an alternating magnetic field  [Not invited]
    M. Tateno; M. Suzuki; T. Mizuki; H. Morimoto
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Synthesis of carbon-encapsulated magnetic nanoparticles and their application to enzyme immobilization  [Not invited]
    T. Sawada; T. Hasumura; T. Fukuda; Y. Hayasaki; S. Iwai; T. Maekawa; H. Morimoto
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Dynamics of chemically modified magnetic particles on a glass substrate induced by a rotational magnetic field  [Not invited]
    Y. Hayashi; Y. Nagaoka; H. Morimoto; T. Maekawa
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Hysteresis loss heating of multi-functional iron-containing carbon nanotubes  [Not invited]
    T. Okada; Y. Nagaoka; S. Iwai; H. Morimoto; N. Grobert; T. Maekawa
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • Enhancement of biochemical reactions utilising nano/micro materials  [Not invited]
    N. Tachihara; Y. Nagaoka; T. Mizuki; H. Morimoto; T. Maekawa
    9th International Conference on Surfaces, Coatings and Nano-Structured Materials (NANOSMAT 2014)  2014/09
  • S. Aoki; Y. Nagaoka; T. Ukai; H. Morimoto; T. Maekawa
    International Soft Matter Conference 2013  2013/09
  • S. Nagaoka; Y. Hayashi; Y. Nagaoka; H. Morimoto; T. Maekawa
    International Soft Matter Conference 2013  2013/09
  • T. Sawada; T. Hasumura; T. Maekawa; H. Morimoto
    International Soft Matter Conference 2013  2013/09
  • M. Suzuki; A. Aki; T. Mizuki; R. Usami; T. Maekawa; H. Morimoto
    International Soft Matter Conference 2013  2013/09
  • S. Suzuki; M. Suzuki; T. Mizuki; H. Morimoto
    International Soft Matter Conference 2013  2013/09
  • H. Hayashi; M. Suzuki; T. Mizuki; H. Morimoto
    International Soft Matter Conference 2013  2013/09
  • Y. Nagaoka; T. Ukai; M. Suzuki; R. Hironaga; H. Morimoto; N. Grobert; T. Maekawa
    7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)  2012/09
  • T. Iida; H. Morimoto
    7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)  2012/09
  • S. Suzuki; M. Suzuki; T. Mizuki; H. Morimoto
    7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)  2012/09
  • A. Aki; N. Hirosawa; H. Morimoto; Y. Sakamoto; T. Maekawa
    7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)  2012/09
  • M. Suzuki; A. Aki; T. Mizuki; R. Usami; T. Maekawa; H. Morimoto
    7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)  2012/09
  • B. G. Nair; Y. Nagaoka; T. Fukuda; T. Mizuki; H. Morimoto; D. S. Kumar; T. Maekawa
    Nanocon2011  2011/09
  • M. Suzuki; A. Aki; T. Mizuki; R. Usami; T. Maekawa; H. Morimoto
    15th International Symposium on Applied Electromagnetics and Mechanics  2011/09
  • T. Hashimoto; Y. Nagaoka; T. Mizuki; H. Morimoto; T. Maekawa
    15th International Symposium on Applied Electromagnetics and Mechanics  2011/09
  • K. Hoshino; T. Ukai; T. Maekawa; H. Morimoto
    15th International Symposium on Applied Electromagnetics and Mechanics  2011/09
  • T. Ukai; H. Morimoto; T. Maekawa
    International Soft Matter Conference 2010  2010/07
  • R. Hironaga; Y. Nagaoka; T. Ukai; H. Morimoto; T. Maekawa
    International Soft Matter Conference 2010  2010/07
  • M. Suzuki; A. Aki; T. Mizuki; R. Usami; T. Maekawa; H. Morimoto
    International Soft Matter Conference 2010  2010/07
  • Y. Nagaoka; H. Morimoto; T. Maekawa
    International Soft Matter Conference 2010  2010/07

Industrial Property Rights

  • 特願20100158657:US patent "Method for manipulation using rotational magnetic field"  2005年/08/12
    Toru Maekawa, Hisao Morimoto, Yutaka Nagaoka

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2021/04 -2024/03 
    Author : 森本 久雄
     
    2021 年度は，本研究で使用するシグマアルドリッチ社製 磁性カーボンナノ粒子の特性を調べた．この粒子は鉄のコアに炭素を被覆したものであるが透過型電子顕微鏡によって粒子を観察し，鉄のコアのサイズおよび外側の炭素層の厚みを測定した．次にこの粒子を PCR の反応溶液に分散させて通常のサーマルサイクラーで PCR を行い，粒子が PCR におよぼす効果を調べた．PCR で用いられる DNA ポリメラーゼはナノ粒子表面に吸着し失活してしまうことから，これを防ぐために粒子表面を BSA（ウシ血清アルブミン）でブロッキングすることにした．BSA で表面修飾された粒子は，その濃度が十分低い場合には PCR に影響をおよぼすことは無く DNA の増幅量にも変化が無いことが確認された．次に，磁性カーボンナノ粒子の光発熱効果を利用した PCR を行うための実験システムを構築した．本システムでは，磁性カーボンナノ粒子が分散した PCR 反応溶液に Ti:Al2O3 レーザー（波長 800 nm）を照射して溶液を加熱する．一方，溶液が封入された容器（PCR チューブ）は氷水で冷却されたコイル内に設置されており，レーザー照射を止めると溶液温度は減少する．レーザー照射の ON/OFF はコンピュータによって制御された光学シャッターによって行うことが出来る．本システムを用いてレーザーを照射した際の溶液の温度上昇ならびに照射を停止した際の温度減少をサーモカメラで測定した．さらにこのデータをもとに 2 段階 PCR を行うためのシャッターの開閉タイミングについて検討した．本システムによって 2 段階 PCR を行い，ターゲット DNA の増幅に成功した．
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2018/04 -2022/03 
    Author : Morimoto Hisao
     
    In this study, the self-organization and the heat generation of ferromagnetic nanoparticles subjected to a radio frequency alternating magnetic field were investigated numerically and experimentally aimed at application to magnetic hyperthermia for cancer therapy. It was found that ferromagnetic nanoparticles formed clusters under an ac magnetic field and the heat generation efficiency of the nanoparticles was varied depending on the cluster structures. The dependence of the cluster structures and the amount of heat generated by the nanoparticles on the experimental parameters such as the amplitude of the ac magnetic field and the volume fraction of the nanoparticles was analyzed and the effect of the cluster formation on the heat generation efficiency of the nanoparticles was clarified.
  • 高周波交流磁場中における磁性粒子/酵素複合体クラスターの発熱および酵素活性の解明
    科学研究費 基盤研究（Ｃ）（一般）
    Date (from‐to) : 2015/04 -2018/03 
    Author : 森本 久雄
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2010/04 -2013/03 
    Author : MORIMOTO Hisao
     
    A new nano/micro-scale heating method was developed combining the hysteresis loss heating of ferromagnetic particles under a high frequency alternating magnetic field and the method of manipulating magnetic particles using an external magnetic field. It was shown that the activation and manipulation of enzymes immobilized on ferromagnetic particles can be carried out utilizing the present method.
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2001 -2003 
    Author : 森本 久雄
     
    本研究の目的は,液体中に分散された数nmからサブミクロンサイズの微粒子系(コロイド粒子系)において発現する自己組織化現象を理論的・実験的に明らかにし,その工学的応用について検討することである.今年度得られた研究成果を以下にまとめる. 1.理論的解析 平衡・非平衡ブラウン動力学法により強磁性コロイド粒子のクラスター構造を解析した.無磁場における強磁性粒子は,互いに双極子モーメントの向きに結合して鎖状クラスターを形成するが,それら鎖状クラスターは屈曲したりクラスター内の部分同士が相互作用して,リング構造などの多様な構造を示す.本研究では,この鎖状クラスターを強磁性粒子を連結したフレキシブルチェーンでモデル化し,その平衡構造を詳細に解析した.粒子間相互作用がそれほど強くない場合には主にチェーンおよびリング構造が形成される.本解析では,両者の生成比を定量的に評価した.粒子間相互作用が強くまたクラスター構成粒子数が多くなると,チェーンが巻きついたスパイラル構造など複雑な構造が形成される.本解析では,このような複雑構造の形成についても議論した. 2.実験による解析 交流磁場中における強磁性コロイド粒子クラスター形成の顕微鏡観察実験を行った.強磁性粒子は直流磁場中において磁場方向に鎖状クラスターを形成するが,交流磁場を印加するとより太い鎖状クラスターが形成された.このクラスター形成は,交流磁場中における強磁性粒子の回転運動と密接に関係していると考えられることから,今後ブラウン動力学法とあわせた詳細な解析が必要である.また,直流磁場中における常磁性粒子クラスター形成の光散乱実験を行い,磁場中のクラスターサイズ分布が得られた.今後は本実験系を交流および回転磁場中での観察が可能となるよう発展させていく予定である. 本年度は,熱力学および複雑系のスローダイナミックスの国際会議等に参加し,成果発表を行った.

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