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NakashimaKazuhiro

NakashimaKazuhiro

    Department of Mechanical Engineering　Associate Professor
    Research Institute of Industrial Technology　Researcher
    Course of Advanced Mechatronics Systems　Associate Professor
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Last Updated :2025/06/06

Researcher Information

Research funding number

  • 70315109

Research Interests

  • ハイドロゲル   人工軟骨   境界潤滑   摩擦   蛋白質吸着   人工関節   バイオトライボロジー   

Research Areas

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Machine elements and tribology / biotribology
  • Life sciences / Biomedical engineering

Academic & Professional Experience

  • 2021/04 - Today  Toyo UniversityFaculty of Science and Engineering Department of Mechanical Engineering准教授
  • 2017/10 - 2021/03  Teikyo UniversityFaculty of Fukuoka Medical Technology Department of Medical Technology准教授
  • 2007/04 - 2017/09  Kyushu UniversityFaculty of Engineering助教
  • 1999/04 - 2007/03  Kyushu UniversitySchool of Engineering助手

Education

  • 1997/04 - 1999/03  Kyushu University  Faculty of Engineering  機械工学専攻
  • 1993/04 - 1997/03  Kyushu University  School of Engineering  機械エネルギー工学科

Association Memberships

  • バイオトライボロジー 研究会   日本臨床バイオメカニクス学会   日本トライボロジー学会   日本機械学会   

Published Papers

Books etc

  • 医療系技師のための微分・積分・微分方程式
    (Single work)DTP出版 2020/04

Conference Activities & Talks

  • Measurement of the Surface Free Energy of BSA Film Adsorbed on a Gold Substrate  [Not invited]
    Kazuhiro Nakashima
    トライボロジー会議2024春東京  2024/05  Oral presentation
  • 蛋白質吸着膜のエネルギー散逸過程解明のための予備的検討  [Not invited]
    中嶋和弘
    第44回バイオトライボロジシンポジウム  2024/03  Oral presentation
  • Estimation of the Shear Strength of Adsorbed Albumin and γ-globulin Molecules under Fluid Shear Stress  [Not invited]
    Kazuhiro Nakashima
    9th International Tribology Conference, Fukuoka 2023  2023/09  Oral presentation
    Estimation of the Shear Strength of Adsorbed Albumin and γ-globulin Molecules under Fluid Shear Stress  [Not invited]Kazuhiro Nakashima9th International Tribology Conference, Fukuoka 2023  2023/09  Or...See More
  • Relationship between Friction and Adsorption/Desorption Behavior of Adsorbed Film Composed of 2 Types of Protein  [Not invited]
    Fangcheng Zhong; Kazuhiro Nakashima; Yoshinori Sawae
    9th International Tribology Conference, Fukuoka 2023  2023/09  Oral presentation
    Relationship between Friction and Adsorption/Desorption Behavior of Adsorbed Film Composed of 2 Types of Protein  [Not invited]Fangcheng Zhong; Kazuhiro Nakashima; Yoshinori Sawae9th International Tri...See More
  • Measurement of The Adsorption Amount of Proteins on Au and Cr Surfaces  [Not invited]
    Nakashima K; Sawae Y
    Biotribology Fukuoka 2023  2023/09  Oral presentation

MISC

Industrial Property Rights

  • 特開2015-063126:ハイブリッドゲル、及びハイブリッドゲルの製造方法  2015/04/09
    鈴木淳史, 佐々木沙織, 村上輝夫, 中嶋和弘, 鎗光清道, 坂井伸朗  国立大学法人横浜国立大学, 国立大学法人九州大学, 国立大学法人九州工業大学
  • 特開2008-290398:金属表面に四フッ化エチレン樹脂転移膜を形成する方法、及びそれを用いた摺動部材  2008/12/04
    澤江義則, 中嶋和弘, 山口晃, 伊藤竜馬, 村上輝夫  国立研究開発法人産業技術総合研究所

Awards & Honors

  • 2011/02 International HYDROGENIUS and I2CNER International HYDROGENIUS and I2CNER Joint Symposium Distinguished Presentation Award
  • 2007/03 日本生体医工学会 九州支部 研究奨励賞
  • 2004/11 日本トライボロジー 学会 日本トライボロジー学会 2004 秋 鳥取 ベストプレゼンテーション賞

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2021/04 -2024/03 
    Author : 中嶋 和弘; 佐藤 正広
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Date (from‐to) : 2017/04 -2021/03 
    Author : Sawae Yoshinori
     
    This study aimed to explore details of the sophisticated lubrication mechanism in a natural synovial joint which always articulates smoothly with extremely low friction resistance. The highly hydrated and permeable polymer hydrogel was used as a physical model of articular cartilage and used in the friction test to evaluate the lubricating function of biological molecules contained in synovial fluid. As a result, a complex of hyaluronic acid and phosphides exhibited an excellent lubrication ability on the cartilage model. The pressurized water content of the cartilage model under the contact load played an important role to activate the lubricating effect of synovial constituents by preventing the adsorption of protein molecules on the model surface. The lubrication effect of synovial constituents was further enhanced by combining with extra-cellular matrix synthesized and supplied from cultured chondrocytes.
    Study on self-forming and self-healing mechanism of natural superlubricity in articular cartilage surfaceJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid f...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Date (from‐to) : 2016/04 -2020/03 
    Author : Kudo Susumu
     
    The increase of the blood flow during local cooling is known as cold-induced vasodilation (CIVD). However, the exact mechanism is still subject to debate. To clear the mechanism, we measured the finger skin blood flow. We showed that endothelial NO-independent activity was significantly higher and neurogenic activity significantly lower at vasoconstriction than at baseline. Additionally, the differences in both activities were significant between vasoconstriction and prior to CIVD, suggesting that the increase of endothelial NO-independent activity and the decrease of neurogenic activity may contribute to CIVD. We also analyzed H2O2 as a NO independent factor using cultured endothelial cells. We showed the increase of H2O2 in lower temperature condition. This increase suggested that H2O2 may be related to CIVD. We further analyzed SNPs using GWAS technique. We showed that PATJ, ROCK2, LGR are considered to be candidate genes for CIVD.
    Macro and micro analysis for physiological polytypism of cold-induced vasodilationJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research ...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2016/04 -2019/03 
    Author : MURAKAMI TERUO
     
    The detailed mechanism of adaptive multimode lubrication in natural synovial joints has been elucidated and subsequently those results have been applied to develop innovative poly(vinyl alcohol) (PVA) hydrogel cartilage. It was shown that the reinforcement by PVA fiber for PVA hydrogel promoted the interstitial fluid pressurization and reduced friction. For PVA hybrid hydrogel of optimized laminated structure, the optimum gamma-ray irradiation as sterilization and cross-linking treatment to the PVA hybrid hydrogel was effective to reduce wear. The PVA hybrid hydrogel with optimized composite structure as a single layer was developed which showed low friction and minimum wear even at high contact pressure.
    Robustness enhancement and optimization for bionic artificial hydrogel cartilage with superlubricityJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Sc...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2015/04 -2018/03 
    Author : Nakashima Kazuhiro
     
    It was pointed out that albumin and g-globulin included in natural synovial fluid can form cooperative film on joint prosthesis material and as a result the adsorbed film make friction low. In this study, friction and adsorption properties of albumin and g-globulin were investigated to clarify the mechanisms of maintaining low friction. Albumin showed low friction property and g-globulin showed high adsorption amount. The different property of two kind of protein indicates albumin molecule exhibits low friction of joint prosthesis and g-globulin protects joint prosthesis material from wear. These results suggest that adsorbed protein film shows low friction due to different properties of albumin and g-globulin forming cooperative adsorbed film.
    Evaluation of joint prosthesis rubbing surface with low friction property by clarifying adsorption mechanisms of protein moleculesJapan Society for the Promotion of Science：Grants-in-Aid for Scientifi...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Specially Promoted Research
    Date (from‐to) : 2011 -2015 
    Author : MURAKAMI Teruo; SAWADA Renshi; SAWAE Yoshinori; YAMAGUCHI Tetsuo; NAKASHIMA Kazuhiro; OKAZAKI Ken; MATSUDA Shuichi; SAKAI Nobuo; SUZUKI Atsushi; YARIMITSU Seido; TANAKA Yoshimi; HIRASHIMA Yumiko; HIROKAWA Shunji; OMATA Seiji; SASAKI Saori
     
    The detailed mechanism of adaptive multimode lubrication in natural synovial joints has been elucidated and subsequently those results will be applied to develop innovative artificial cartilage. It was shown that friction and wear properties of hydrogels depend on the types of hydrogels and lubricants. The superior lubrication mechanism of articular cartilage and poly (vinyl alcohol) hydrogels are evaluated from the viewpoint of biphasic and boundary lubrication mechanisms. The PVA hybrid hydrogel artificial cartilage as optimized laminated structure has shown superior lubricity with extremely low friction and minimum wear.
    Elucidation of adaptive lubrication mechanism with low friction and minimum wear in natural synovial joints and development of artificial hydrogel cartilage with super lubricity based on bionic design...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2012/04 -2014/03 
    Author : NAKASHIMA Kazuhiro
     
    Protein adsorbed film on joint prosthesis material affecting tribological property was evaluated by using electrochemical method. Albumin and gamma-globurin contained in natural cynovial fluid was selected for measurement. The combination of ultra-high molecular weight polyethylene (GUR1050) and CoCrMo alloy (ASTMF75) was employed. The potential between CoCrMo alloy and protein solution was measured to understand the behaviour of protein adsorption. Albumin was easily peeled off by shear force, it means the adsorption is weak. Gamma-globulin did not show desorption by shear force. Therefore, the difference of adsorption strength and stability is essence to form protein adsorption film.
    Evaluation of adsorbed protein film on joint prosthesis material by using electrochemical methodJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young ...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2011/04 -2014/03 
    Author : SAWAE Yoshinori; NAKASHIMA Kazuhiro; WATANABE Masao
     
    The agarose construct containing freshly isolated primary chondrocytes was prepared as a regenerated cartilage tissue model and cultured under the traction loading applied to the model surface. Then, the effects of the traction loading on the functional development and degradation of lubricious cartilage tissues were examined. Results indicated that the traction loading on the tissue surface could stimulate the biosynthesis of extracellular matrix and bring anisotropic nature in the regenerated cartilage tissue. However, the enhancement in the lubricating ability of cultured tissue surface could not be confirmed experimentally. However, degenerative effects of the excessive shear deformation that would be caused by the disruption of lubrication mechanism could be confirmed, since the cell viability in the agarose construct dropped drastically when the shear strain exceeded 5%.
    Study on functional development, homeostasis and degradation of lubrication mechanism in living tissue using regenerated cartilage model cultured under traction loadingJapan Society for the Promotion ...See More
  • 日本学術振興会：科学研究費助成事業 基盤研究(A)
    Date (from‐to) : 2009 -2011 
    Author : 村上 輝夫; 澤江 義則; 中嶋 和弘; 澤田 廉士; 坂井 伸朗
     
    生体関節は、定常歩行運動時にはマイクロレベルを含む弾性流体潤滑により低摩擦・低摩耗を維持し、摩擦増大や表面損傷の発生をもたらす局所的接触が発生しうる薄膜潤滑の場合には、巧みな多種のモードの潤滑機構を有することにより極低摩擦・極低摩耗を実現している。このような潤滑機構は、多モード適応潤滑機構と称されているが、詳細については未解明な点も多い。そこで、本研究では、軟骨表面の複雑な構造の実態を各種の手法で明確化するとともに、極性分子の吸着挙動と水和潤滑効果の相互関係と協調的潤滑機能への寄与を探求した。成果の概要を略述する。 1.水和潤滑に対する生体関節軟骨摩擦面吸着膜形成の影響の解明:除荷・再負荷摩擦試験により軟骨表面水和回復と関節液成分吸着膜の強調作用を明確化できた。2.生体関節軟骨と軟骨細胞の変形・摩擦挙動の実測と数値解析:固液二相体としての関節軟骨の可視化圧縮試験と圧縮及び往復動状態の有限要素解析により、モデル化を可能とするとともに,深さ依存弾性特性・透過の圧密特性・線維スプリング効果などの重要性を把握できた。3.軟骨細胞・滑膜細胞への摩擦刺激・力覚応答試験:圧縮刺激に対する軟骨細胞の応答を明確化した。滑膜組織からの滑膜細胞の単離と培養を可能とし、培養組織の評価を行った。4.軟骨模擬材料および軟骨のマイクロトライボ試験:ポリビニルアルコールハイドロゲル模擬軟骨と関節軟骨の比較試験により、ナノ構造特性の相違の影響を明らかにし、低摩擦化への指針を得た。5.マイクロ血流センサによる軟骨部流動現象の非侵襲計測:標準材料や軟骨におけるシグナルの計測を行い、計測手法の基盤を構築し、酵素処理などの影響を調査した。上述成果について統合的に評価を行うことにより、生体の巧みな多モード自律潤滑機構の未解明部分の複数事象を明らかにできた。
    極低摩擦・極低摩耗生体関節に学ぶ多モード自律潤滑機構の解明日本学術振興会：科学研究費助成事業 基盤研究(A)Date (from‐to) : 2009 -2011 Author : 村上 輝夫; 澤江 義則; 中嶋 和弘; 澤田 廉士; 坂井 伸朗 生体関節は、定常歩行運動時にはマイクロレベルを含む弾性流体潤滑により低摩擦・低摩耗を維持し、摩擦増大や表面損傷の発生をもたらす局所的接触が発生しうる...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2008 -2009 
    Author : NAKASHIMA Kazuhiro
     
    Hybrid artificial cartilage was developed and was evaluated on friction property. PVA hydrogel was used as basic material, and condrocyte was introduced on PVA hydrogel surface, then hybrid artificial cartilage with extra-cellular matrix was developed. Hybrid artificial cartilage showed that coefficient of friction was decreased with incubating time. Therefore, development of hybrid artificial cartilage was successful.
    Development and evaluation of hybrid artificial cartilageJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)Date (from‐to) : 2008 -2...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas
    Date (from‐to) : 2003 -2006 
    Author : MURAKAMI Teruo; SAWAE Yoshinori; NAKASHIMA Kazuhiro; SAKAI Nobuo
     
    The increase of elder persons disabled with walking ability due to osteoarthritis, rheumatoid arthritis or damages of natural synovial joints is anticipated with progress of population of aged people particularly in Japan. In natural synovial joint, the articular cartilage plays important roles in load-carrying mechanism and lubrication mechanism. The initiation of osteoarthritis is considered to be brought about by the deficiency of lubricating ability in synovial joints and loss of load-carrying capacity of articular cartilage. The articular cartilage is composed of extracellular matrix (ECM) and chondrocyte. The object of this research is to elucidate the stress-strain behaviors of articular cartilage including chondrocytes and the adaptive multimode lubrication mechanism in natural synovial joints from the macro-, micro- and nanoscopic viewpoints, to prevent the progress of osteoarthritis and to improve the function in regenerated cartilage. The confocal laser scanning microscopy (CLSM) was used to estimate the local strain of articular cartilage under compression by observing the fluorescent images of stained chondrocytes. The time-dependent and depth-dependent strain behaviors of articular cartilage were investigated by CLSM. These mechanical behaviors were evaluated by the biphasic finite element method (FEM). These stress-strain behaviors have an influence on metabolism controlled by chondrocytes which is expected to produce surrounding ECM including proteoglycan and collagen. The depth-dependent profile deformation and time-dependent strain behavior of semi-cylindrical cartilage specimen was simulated by biphasic finite element analyses considering depth-depending elastic modulus. The correspondence to the peak compressive stress and following stress relaxation immediately after compression at high strain rate was attained by consideration of one order raising of elastic modulus or by introducing of spring element like collagen fiber to biphasic model. Furthermore, the effect of cyclic compressive stimulation on cultured chondrocytes was indicated by an increase in elastic modulus of chondrocyte-agarose construct.
    Micro- and Nano-Scopic Biomechanics of Articular Cartilage Focusing Chondrocytes and Surrounding TissueJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for...See More
  • 日本学術振興会：科学研究費助成事業 若手研究(B)
    Date (from‐to) : 2004 -2005 
    Author : 中嶋 和弘
     
    前年度までの研究により蛋白質が摩擦面に吸着することで摩耗を低減させることが明らかとなった.ハイドロゲルの摩耗は潤滑液に含まれる蛋白質の種類・添加量・添加比に依存した.蛋白質として生体関節液に含まれるアルブミン及びγ-グロブリンを使用したが,それぞれ摩擦摩耗に対する役割が異なると思われた.蛋白質の吸着挙動は分子量・親疎水基の割合・電荷の状態等に影響されると思われる.蛋白質の立体構造は上記の蛋白質の特性に影響されるため,総合的に吸着に対する蛋白質の挙動の差異を調べることができる.本年度は蛋白質の立体構造に着目し,その影響について調査した.蛋白質の立体構造を知るために円二色性分散計を用いた。それぞれの蛋白質の円二色性を測定することで立体構造がどのようになっているかを把握することができる.その結果,アルブミンはαヘリックス構造を,γ-グロブリンはβシート構造をそれぞれ多く有することが明らかとなった.さらにそれぞれの立体構造の摩擦摩耗への影響を調べるため,往復動摩擦試験を行った.その結果、αヘリックス構造はβシート構造に比べ吸着力が弱く,せん断を受けると表面から脱落しやすいことが明らかとなった.前年度までの研究からアルブミンとγ-グロブリンが層状に吸着した境界膜において摩耗低減効果がみられたことから,吸着力の弱いαヘリックス構造を多く有するアルブミンと強固な吸着力を持つγ-グロブリンがそれぞれ摩擦低減、摩耗低減効果を有すると思われる.また,加熱により立体構造を変化させるとアルブミンでは摩擦が低減することが観察された.加熱によりαヘリックス構造が失われランダムコイルとなり吸着力が増加したために境界潤滑膜としての機能が向上したと思われる.
    人工軟骨候補材料の蛋白質境界膜による低摩耗化のメカニズムの解明と潤滑液の最適設計日本学術振興会：科学研究費助成事業 若手研究(B)Date (from‐to) : 2004 -2005 Author : 中嶋 和弘 前年度までの研究により蛋白質が摩擦面に吸着することで摩耗を低減させることが明らかとなった.ハイドロゲルの摩耗は潤滑液に含まれる蛋白質の種類・添加量・添加比に依存した.蛋白質として生体...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Date (from‐to) : 2003 -2005 
    Author : MURAKAMI Teruo; SAWAE Yoshinori; NAKASHIMA Kazuhiro; SAKAI Nobuo
     
    The object of this research is to elucidate the adaptive multimode lubrication mechanism in natural synovial joints in relation to the self-organization and restoration from the hierarchic and microscopic viewpoints, to prevent the progress of osteoarthritis and to improve the function in regenerated cartilage. The atomic force microscopy (AFM) was applied to observe the morphological changes in articular cartilage surfaces removed from knee joints with osteoarthritis and porcine cartilage at different friction levels during rubbing experiments. The corresponding force-distance curves were examined to estimate the mechanical properties. The confocal laser scanning microscopy (CLSM) was used to estimate the local strain of articular cartilage under compression by observing the fluorescent images of stained chondrocytes. The morphology and distribution of chondrocytes in articular cartilage were investigated by CLSM. Three-dimensional numerical analysis based on biphasic finite element method was conducted to examine the influence of compressive stimulation on chondrocyte in articular cartilage. Lubricating gel film composed of proteoglycan appears to protect the bulk cartilage and maintain low friction even under severe rubbing. The proteoglycan in gel film is supplied through production by chondrocyte. The changes in stress-strain around chondrocyte was examined, because appropriate stimulation to chondrocyte can give an influence on the production of proteoglycan. Another protective mechanism with low friction is given by adsorbed film formation on the rubbing surface. The tribological property of polyvinyl-alcohol (PVA) hydrogel specimen as artificial cartilage or a model of cartilage was examined in hyaluronate solution containing globular serum proteins. The appropriate constituents composed of albumin and γ-globulin resulted in lower wear and lower friction. The difference in adsorptional behavior was clearly confirmed with in situ observation of fluorescent images of proteins. The total internal reflection fluorescence microscopy (TIRFM) was successfully applied to observe adsorptional behavior of proteins.
    Elucidation of Adaptive Multimode Lubrication Mechanism, Self-Organization and Restoration Mechanism in Natural Synovial JointsJapan Society for the Promotion of Science：Grants-in-Aid for Scientific R...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2001 -2002 
    Author : 中嶋 和弘
     
    臨床応用されている人工関節の寿命は数年から十数年であり,特に若年の患者に対しては再置換術が必要となる問題がある.人工関節の寿命決定因子は摩擦面の摩耗による摩耗粉が原因となる報告が多く,摩耗の低減が人工関節を長寿命化させる上で最も重要な因子であることが指摘されている.人工軟骨にはPVA(polyvinyl alcohol)ハイドロゲルを使用し,潤滑モードを混合潤滑から流体潤滑主体とすることにより摩擦摩耗の低減を試みた.ゲルは含水性であるため,シビアな条件下でも内部からの水の滲出により直接接触を防ぎ,低摩擦とする効果が期待されている. PVAハイドロゲルを摩擦面に使用し直接接触が発生する厳しい試験条件においてその摩擦摩耗特性について調査した.PVAハイドロゲル同士を摩擦面にした場合,潤滑液に添加した蛋白質により摩耗の程度に差異が観察された.生体関節液に含まれる蛋白質のうち代表的なアルブミン及びγ-グロブリンを潤滑液(ヒアルロン酸溶液)へ添加したととろ,それぞれ単体で潤滑液に添加するよりも2種の蛋白質を混合した潤滑液を使用することで摩耗の低減が観察された.生体関節のようにA/G比を2/1とするとかなりの摩耗の低減が観察された.また,蛋白質を過剰に添加すると摩耗が促進された.すなわち,PVAハイドロゲルの摩耗特性は潤滑液に含まれる蛋白質に大きく依存することが明らかとなつた.AFMにより表面膜の観察を行い摩耗保護作用について調べた.ゲルは高倍率での観察が困難であるためPVAと同程度の親水性の表面を持つガラスを用いた.アルブミンのみを添加した場合では残留膜の吸着力が弱く,脱落しやすいことが明らかとなった.γ-グロブリンを単体で添加した場合には吸着力が強いことが観察された.このことから,2種を混合して用いた場合に膜内部に低せん断層をもつ潤滑性・耐摩耗性に優れた境界膜が得られることが明らかにされた.
    高機能人工軟骨を有する人工関節の開発と実用化に関する研究Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)Date (from‐to) : 2001 -2002 Author : 中嶋 和弘 臨床応用されている人...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2000 -2001 
    Author : MURAKAMI Teruo; NAKASHIMA Kazuhiro; SAWAE Yoshinori; OHTSUKI Nobuo
     
    The object of this research is to elucidate the adaptive multimode lubrication mechanism in natural synovial joints in relation to the self-organization from the hierarchic and microscopic viewpoints. The systematic investigation was performed to clarify the adaptive multimode lubrication mechanism in natural synovial joints. Experimental evaluation of fluid film formation in knee joint model in simulator and numerical analysis showed the important role of elastohydrodynamic lubrication during walking. In friction tests of pig shoulder joints by pendulum method, the influence of hyaluronate concentration on frictional behavior under high and low load conditions was clarified in related to removal of adsorbed films or addition of phospholipid or proteins. The boundary lubrication by adsorbed film composed of phospholipids, proteins and glycoproteins was clearly shown by an increase in friction after removal of adsorbed film. Addition of phospholipid liposome and γ-globulin was effective in lowering of friction. The atomic force microscopy (AFM) was applied to observe the changes in articular cartilage surfaces at different friction levels during rubbing process. The corresponding force-distance curves at several friction levels were examined. These results indicated that lubricating roles of adsorbed film and gel film change with progressive wear process. The tribological property of polyvinyl-alcohol (PVA) hydrogel specimen as artificial cartilage was compared with that of natural articular cartilage to clarify the difference between both materials. The three-dimensional numerical analysis based on finite element method was conducted to examine the influence of compressive stimulation on chondrocyte in articular cartilage. The morphology and distribution of chondrocytes in articular cartilage were investigated by confocal laser scanning microscopy (CLSM) to construct the three-dimensional model. It was noticed that the local strain near surface had larger value than average one immediately after compressive loading and recovered to the average level. This local high strain has the possibility to have a remarkable effect on the chondrocyte located in those zones. The changes in strain were observed by CLSM.
    Elucidation of Adaptive Multimode Lubrication Mechanism and Self-Organization in Natural Synovial JointsJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid fo...See More
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Date (from‐to) : 1999 -2001 
    Author : MURAKAMI Teruo; NAKASHIMA Kazuhiro; SAWAE Yoshinori; OHTSUKI Nobuo; MIURA Hiromasa; IWAMOTO Yukihide
     
    The object of this research is to develop the systems for optimum design, trial production and evaluation of knee prostheses with artificial cartilage and meniscus, which have an adaptive multimode lubrication mechanism. The systems for optimum design including geometrical analysis, trial production and simulator testing was developed. The two-channel knee joint simulator was manufactured to simulate the walking motion as three-dimensional mode. Tribological performance of artificial cartilage materials such as hydrogels and polyurethane was evaluated. The rubbing specimens and tibial component of PVA(polyvinylalcohol) hydrogel were prepared by freezing-thawing method. PVA hydrogel with high water content exhibited the lower friction than that with low water content, but the friction increased with repetition of walking cycles. The lubricant constituents, particularly hyaluronic acid and protein had a remarkable effect on friction and wear of compliant materials. It was shown that the 5 cycles for freezing-thawing process was the optimum condition to attain the highest stiffness and strength and minimum wear. On the starting friction of compliant material after static loading with different duration, it increased with loading time. The application of high frequency AC electric field was effective in reduction of friction for conductive materials. High water content for PVA hydrogel and the immersion in hyaluronate solution for polyurethane were effective in reducing starting friction. The worn surfaces of polyethylene components for several retrieved knee prostheses of anatomical design were observed, where the delamination and pitting as fatigue wear were discriminated. To elucidate the fatigue wear mechanism, the finite element method was applied as elasto-plastic contact analysis, in which the influence of component thickness and rolling motion on plastic deformation was clarified. From the clinical viewpoint, the kinematic analysis of total knee arthroplasty by pattern matching method was conducted. The changes in knee alignment after total knee arthroplasty and anatomic variation were evaluated. It was shown that geometrical design with better congruity or with appropriate radius, and the application of compliant materials accompanied with boundary lubricating ability enhance the lubricating performance. The design direction including the influence of tensile stress on osteoclast was shown for clinical application.
    Development of Optimum Design, Trial Production and Evaluation Systems for Knee Joint Prostheses with Artificial Cartilage and Meniscus Similar to Natural Synovial JointsJapan Society for the Promotio...See More

Teaching Experience

  • Advanced Dynamics
    Toyo University
  • Mathematical Modeling of Mechanical Systems
    Toyo University
  • Engineering Dynamics 2
    Toyo University
  • Mathematics for Mechanical Engineering 2
    Toyo University
  • Exercises in Calculus B
    Toyo University
  • Calculus A
    Toyo University

Academic Contribution

  • 第42回バイオトライボロジーシンポジウム
    Date (from-to) :2023/03/17-2023/03/17
    Role: Planning etc
    Type: Competition etc
    Organizer, responsible person: バイオトライボロジー研究会
    東洋大学 川越キャンパス
  • The 11th International Biotribology Forum and The 40h Biotribology Symposium, Secretariat
    Date (from-to) :2019/09/15-2019/09/16
    Role: Planning etc
    Type: Competition etc
    Organizer, responsible person: バイオトライボロジー 研究会
    The 11th International Biotribology Forum and The 40h Biotribology Symposium, SecretariatDate (from-to) :2019/09/15-2019/09/16Role: Planning etcType: Competition etcOrganizer, responsible person: バイオ...See More
  • 第9回 日中トライボロジー先端フォーラム 幹事
    Date (from-to) :2018/04/12-2018/04/14
    Role: Planning etc
    Type: Academic society etc
    Organizer, responsible person: 日本トライボロジー 学会

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