Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2015/04 -2018/03
Author : YANO TOMOHIRO; KOHNO Kakeru; MINEMATSU Ayako
In order to prevent deterioration of bone quality caused by the increase of blood level in homocysteine (HCY) based on genetic polymorphism of methylenetetrahydrofolate reductase (MTHFR), we tried to pick up new vitamins which was effective for suppression of the HCY level in clinical trials with small scale. As well, we screened new functional food components which could prevent bone fracture caused by HCY-induced deterioration of bone quality. As a result, it was identified that combination of vitamin B2 and vitamin E might be effective to suppress the rise in blood level of HCY and that delta-tocotrienol and hydroxytyrosol could act as promising functional food ingredients for prevention of the HCY-induced deterioration of bone quality.