Masako Ota

Researcher Information

Research funding number

• 40442058

J-Global ID

• 201301070192080419

Research Interests

• Homocysteine   ビタミンE   食事調査   biomarker   nutrition   food   

Research Areas

• Life sciences / Nutrition and health science / Exercise and Vitamins
• Humanities & social sciences / Home economics, lifestyle science / Nutrition

Association Memberships

• JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE   

Published Papers

• Resveratrol Can Differentiate Human Melanoma Stem-like Cells from Spheroids Treated With All-trans Retinoic Acid.

  Mina Kanai; Akiho Shinagawa; Masako Ota; Nantiga Virgona; Tomohiro Yano

  Anticancer research 44 (12) 5283 - 5292 2024/12
• Effect of Acute Dietary Nitrate Supplementation on the Changes in Calf Venous Volume during Postural Change and Skeletal Muscle Pump Activity in Healthy Young Adults.

  Anna Oue; Yasuhiro Iimura; Yuichi Miyakoshi; Masako Ota

  Nutrients 16 (11) 2024/05
• Short-term intake of delta-tocotrienol on lipid profiles in healthy subjects

  Naho Serizawa; Yusuke Ninomiya; Akiho Shinagawa; Ayako Minematsu; Yuichi Miyakoshi; Tomohiro Yano; Masako Ota

  Journal of Clinical Biochemistry and Nutrition The Society for Free Radical Research Japan 0912-0009 2024
• Changes in homocysteine and non-mercaptoalbumin levels after acute exercise: a crossover study.

  Akiho Shinagawa; Tomoki Yamazaki; Ayako Minematsu; Naho Serizawa; Yuri Hosoi; Yusuke Ninomiya; Yuichi Miyakoshi; Tomohiro Yano; Masako Ota

  BMC sports science, medicine & rehabilitation 15 (1) 59 - 59 2023/04 [Refereed]
  
• Short-Term Combined Intake of Vitamin B2 and Vitamin E Decreases Plasma Homocysteine Concentrations in Female Track Athletes

  Akiho Shinagawa; Naho Serizawa; Tomoki Yamazaki; Ayako Minematsu; Yuichi Miyakoshi; Tomohiro Yano; Masako Ota

  Dietetics MDPI AG 1 (3) 216 - 226 2022/11 [Refereed]
  
• Effect of Acute Dietary Nitrate Supplementation on the Venous Vascular Response to Static Exercise in Healthy Young Adults.

  Anna Oue; Yasuhiro Iimura; Akiho Shinagawa; Yuichi Miyakoshi; Masako Ota

  Nutrients 14 (21) 2022/10 [Refereed]
  
• Acute dietary nitrate supplementation does not change venous volume and compliance in healthy young adults.

  Anna Oue; Yasuhiro Iimura; Akiho Shinagawa; Yuichi Miyakoshi; Masako Ota

  American journal of physiology. Regulatory, integrative and comparative physiology 323 (3) R331-R339  2022/09 [Refereed]
  
• Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells.

  Kakeru Kohno; Wakana Yamada; Aya Ishitsuka; Miki Sekine; Nantiga Virgona; Masako Ota; Tomohiro Yano

  Bioscience, biotechnology, and biochemistry 84 (3) 526 - 535 2020/03 [Refereed]
  
• How elevated CO2 affects our nutrition in rice, and how we can deal with it.

  Kazuhiro Ujiie; Ken Ishimaru; Naoki Hirotsu; Seiji Nagasaka; Yuichi Miyakoshi; Masako Ota; Takeshi Tokida; Hidemitsu Sakai; Yasuhiro Usui; Keisuke Ono; Kazuhiko Kobayashi; Hiroshi Nakano; Satoshi Yoshinaga; Takayuki Kashiwagi; Jun Magoshi

  PloS one 14 (3) e0212840  2019 [Refereed]
  
• Salt Restriction Affects the Excretions of Minerals (Na, K, Ca, Mg, P and Zn) in the Second Voided Fasting Early Morning Urine.

  Naho Serizawa; Mamoru Nishimuta; Naoko Kodama; Mieko Shimada; Yutaka Yoshitake; Nobuko Hongu; Masako Ota; Tomohiro Yano

  Journal of nutritional science and vitaminology 65 (2) 142 - 147 2019
• Association of Frequency of Milk or Dairy Product Consumption with Subjective Sleep Quality during Training Periods in Japanese Elite Athletes: A Cross-Sectional Study.

  Jun Yasuda; Takahiro Yoshizaki; Kaori Yamamoto; Masae Yoshino; Masako Ota; Takashi Kawahara; Akiko Kamei

  Journal of nutritional science and vitaminology 65 (2) 177 - 183 2019
• Association between Adherence to the Japanese Food Guide Spinning Top and Sleep Quality in College Students.

  Kaori Yamamoto; Masako Ota; Ayako Minematsu; Keiko Motokawa; Yuri Yokoyama; Tomohiro Yano; Yutaka Watanabe; Takahiro Yoshizaki

  Nutrients 10 (12) 2018/12 [Refereed]
  
• Association between Skin Condition and Sleep Efficiency in Japanese Young Adults.

  Takahiro Yoshizaki; Yoshifumi Kimira; Hiroshi Mano; Masako Ota; Ken Iwatsuki; Yuichi Oishi; Takumi Yamane

  Journal of nutritional science and vitaminology 63 (1) 15 - 20 2017
• Estimation of signal molecules related to antimesothelioma effect of tocotrienol ether analogue by cascade analysis on gene expression

  Sugahara Ryosuke; sato Ayami; Uchida Asuka; Shiozawa Shinya; Kono Kakeru; Miyakoshi Yuichi; Ando Akira; Ota Masako; Yano Tomohiro

  VITAMINS THE VITAMIN SOCIETY OF JAPAN 88 (12) 610 - 615 0006-386X 2014
• Systematic review and meta-analysis of vitamin E and cancer

  Kobayashi Minako; Sato Ayami; Sugahara Ryosuke; Ota Masako; Yano Tomohiro

  VITAMINS THE VITAMIN SOCIETY OF JAPAN 88 (9) 478 - 480 0006-386X 2014
• A redox-silent analogue of tocotrienol inhibits cobalt(II) chloride-induced VEGF expression via Yes signaling in mesothelioma cells.

  Ayami Sato; Nantiga Virgona; Akira Ando; Masako Ota; Tomohiro Yano

  Biological & pharmaceutical bulletin The Pharmaceutical Society of Japan 37 (5) 865 - 70 0918-6158 2014
• Redox-inactive analogue of tocotrienol as a potential anti-cancer agent.

  Tomohiro Yano; Ayami Sato; Miki Sekine; Nantiga Virgona; Masako Ota

  Anti-cancer agents in medicinal chemistry 3 13 (3) 496 - 501 1871-5206 2013/03 [Refereed]
  
• Induction of the connexin 32 gene by epigallocatechin-3-gallate potentiates vinblastine-induced cytotoxicity in human renal carcinoma cells.

  Ayami Sato; Miki Sekine; Minako Kobayashi; Nantiga Virgona; Masako Ota; Tomohiro Yano

  Chemotherapy 59 (3) 192 - 9 2013 [Refereed]
  
• Yes is a central mediator of cell growth in malignant mesothelioma cells.

  Ayami Sato; Miki Sekine; Nantiga Virgona; Masako Ota; Tomohiro Yano

  Oncology reports 28 (5) 1889 - 93 2012/11 [Refereed]
  
• Bowman-Birk protease inhibitor from soybeans enhances cisplatin-induced cytotoxicity in human mesothelioma cells.

  Korehito Kashiwagi; Nantiga Virgona; Jin Yamada; Ayami Sato; Masako Ota; Takuya Yazawa; Tomohiro Yano

  Experimental and therapeutic medicine 2 (4) 719 - 724 1792-0981 2011/07 [Refereed]
  

Conference Activities & Talks

• 高齢期におけるパントテン酸欠乏の改善  [Not invited]

  池田拡樹; 関根美季; 矢野友啓; 太田昌子

  栄養学雑誌  2011/09
• 1-I-3 悪性中皮腫に対するγトコトリエノールとスタチンの併用効果(一般演題要旨,日本ビタミン学会第63回大会講演要旨)  [Not invited]

  矢野 友啓; 一之宮 紗紀; 山田 仁; 太田 昌子; 佐藤 洋美; 上野 光一

  ビタミン  2011/04
• 1.パンテチンの腸管運動改善作用について(2)(第420回研究協議会研究発表要旨,ビタミンB研究委員会)  [Not invited]

  木村 修一; 太田 昌子

  ビタミン  2010/08

MISC

• Possibility of prostate cancer prevention based on cancer stem cell theory

  Nobuya Shiozawa; Ryosuke Sugahara; Ayami Sato; Masako Ota; Tomohiro Yano  CANCER RESEARCH  76-  2016/07

Research Grants & Projects

• Investigation of genetic variation and exercise-induced Hcy metabolic kinetics for the prevention of stress fractures in female athletes.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2024/04 -2027/03 

  Author : 峰松 明也子; 太田 昌子; 矢野 友啓
• Factors influencing plasma homocysteine levels for the prevention of stress fractures in female athletes

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2021/04 -2024/03 

  Author : 峰松 明也子; 太田 昌子; 矢野 友啓

   

  令和3年度は、疲労骨折リスクの高い女性長距離陸上選手において、食事条件（エネルギーおよび栄養素摂取量、摂取時刻）を揃え、運動（一過性の持久性運動）を制限する「運動制限期」、制限せず運動部としての活動を行う「運動実施期」で血漿Hcy濃度を調査した。「食事」と「運動」は血漿Hcy濃度に影響を与える因子である。アスリートは、一般成人よりも習慣的に高タンパク質な食事を摂取し、高強度な運動を実施することが予想される。そのため、食事および運動が与える血中Hcy濃度の変化は大きいと仮定した。 全被験者6名中4名において、「運動制限期」の血漿Hcy濃度は、「運動実施期」よりも有意に低かった。また、全被験者の平均においても同様に「運動制限期」の血漿Hcy濃度は、「運動実施期」よりも有意に低かった。さらに、疲労骨折のカットオフ値として報告された値と比較した場合、「運動実施期」は有意に高く、「運動制限期」は有意に低かった。 結論として、女性長距離陸上選手において、食事条件を一定としたとき、運動（一過性の持久性運動）の実施は、翌日の空腹時血漿Hcy濃度を上昇させることが分かった。 血中Hcy濃度に対する食事や運動の影響に焦点を当てている研究はあるものの、結果は矛盾しており決定的ではない。それは、被験者間での食事内容の一致がなされていない、運動の強度、期間、種類等、方法論が非常に多様であり、一貫性のある結論を導くことが困難なためである。それに比べ、被験者は寮生活を送るアスリートに限定し、食事条件（栄養素摂取量、摂取時刻）を揃え、実施運動が明確になっている条件下で血中Hcy濃度の変動を追うことができる点が本研究の独自性である。
• Establishment of a new approach to prevent fracture caused by loss of bone quality

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

  Date (from‐to) : 2015/04 -2018/03 

  Author : YANO TOMOHIRO; KOHNO Kakeru; MINEMATSU Ayako

   

  In order to prevent deterioration of bone quality caused by the increase of blood level in homocysteine (HCY) based on genetic polymorphism of methylenetetrahydrofolate reductase (MTHFR), we tried to pick up new vitamins which was effective for suppression of the HCY level in clinical trials with small scale. As well, we screened new functional food components which could prevent bone fracture caused by HCY-induced deterioration of bone quality. As a result, it was identified that combination of vitamin B2 and vitamin E might be effective to suppress the rise in blood level of HCY and that delta-tocotrienol and hydroxytyrosol could act as promising functional food ingredients for prevention of the HCY-induced deterioration of bone quality.

Other link

researchmap

https://researchmap.jp/g0000209071