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Yusuke Takatsuru

Faculty
Department of Nutritional Sciences
PositionProfessor
Mail
HomepageURL
Birthday
Last Updated :2020/06/05

Researcher Profile and Settings

Association Memberships

  • JAPAN SOCIETY FOR DEMENTIA RESEARCH
  • JAPANESE PSYCHOGERIATRIC SOCIETY
  • THE JAPAN GERIATRICS SOCIETY

Academic & Professional Experience

  •   2015 02  - 2017 08 , Gunma University, Integrative Phisiology, Graduate School of Medicine
  •   2006 04  - 2009 03 , National Institute for Physiological Sciences
  •   2006  - 2008 , National Institute for Physiological Sciences, Department of Developmental Physiology

Research Activities

Research Areas

  • Life sciences, Physiology

Published Papers

  • Food-Intake-Related Hypocupremia Decreased the Number of White Blood Cells and Increased the Concentration of Cholesterol in Serum in Elderly Female, Yusuke Takatsuru, Akemi Seki, Hiro Shimizu, Kikue Takahashi, Noriaki Hattori, International Journal of Gerontology, International Journal of Gerontology, 13, 260 - 262, 10 , Refereed
  • PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia., Jie Shen, Guihua Xu, Runxiu Zhu, Jun Yuan, Yoko Ishii, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yusuke Takatsuru, Junichi Nabekura, Masakiyo Sasahara, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39, (8) 1501 - 1515, 08 , Refereed
  • Early-life stress induces motor coordination dysfunction in adult mice., Kokubo M, Toya S, Amano I, Takatsuru Y, The journal of physiological sciences : JPS, The journal of physiological sciences : JPS, 68, (5) 663 - 669, 09 , Refereed
  • Early-life stress and life., Takatsuru Y, Aging, Aging, 10, (10) 2535 - 2536, 09 , Refereed, Invited
  • Early-life stress induces cognitive disorder in middle-aged mice., Yajima H, Haijima A, Khairinisa MA, Shimokawa N, Amano I, Takatsuru Y, Neurobiology of aging, Neurobiology of aging, 64, 139 - 146, 04 , Refereed
  • Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring., Amano I, Takatsuru Y, Khairinisa MA, Kokubo M, Haijima A, Koibuchi N, Endocrinology, Endocrinology, 159, (4) 1910 - 1921, 04 , Refereed
  • The Effect of Perinatal Gadolinium-Based Contrast Agents on Adult Mice Behavior., Khairinisa MA, Takatsuru Y, Amano I, Erdene K, Nakajima T, Kameo S, Koyama H, Tsushima Y, Koibuchi N, Investigative radiology, Investigative radiology, 53, (2) 110 - 118, 02 , Refereed
  • Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites., Kaneko R, Takatsuru Y, Morita A, Amano I, Haijima A, Imayoshi I, Tamamaki N, Koibuchi N, Watanabe M, Yanagawa Y, The Journal of comparative neurology, The Journal of comparative neurology, 526, (3) 373 - 396, 02 , Refereed
  • High prolactin concentration during lactation period induced disorders of maternal behavioral in offspring., Mitani S, Amano I, Takatsuru Y, Psychoneuroendocrinology, Psychoneuroendocrinology, 88, 129 - 135, 02 , Refereed
  • Role of dopamine on functional recovery in the contralateral hemisphere after focal stroke in the somatosensory cortex., Obi K, Amano I, Takatsuru Y, Brain research, Brain research, 1678, 146 - 152, 01 , Refereed
  • In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice., Khairinisa MA, Takatsuru Y, Amano I, Kokubo M, Haijima A, Miyazaki W, Koibuchi N, Frontiers in endocrinology, Frontiers in endocrinology, 9, Refereed
  • Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring, Taku James Sairenji, Jun Ikezawa, Ryosuke Kaneko, Shinnosuke Masuda, Kaoru Uchida, Yurie Takanashi, Hiroko Masuda, Tomoko Sairenji, Izuki Amano, Yusuke Takatsuru, Kazutoshi Sayama, Kaisa Haglund, Ivan Dikic, Noriyuki Koibuchi, Noriaki Shimokawa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, (49) 13042 - 13047, 12 , Refereed
  • Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice, Asahi Haijima, Ronny Lesmana, Noriaki Shimokawam, Izuki Amano, Yusuke Takatsuru, Noriyuki Koibuchi, JOURNAL OF TOXICOLOGICAL SCIENCES, JOURNAL OF TOXICOLOGICAL SCIENCES, 42, (4) 407 - 416, 08 , Refereed
  • Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors, Izuki Amano, Yusuke Takatsuru, Syutaro Toya, Asahi Haijima, Toshiharu Iwasaki, Helmut Grasberger, Samuel Refetoff, Noriyuki Koibuchi, THYROID, THYROID, 26, (5) 741 - 752, 05 , Refereed
  • Alteration of somatosensory response in adulthood by early life stress, Yusuke Takatsuru, Noriyuki Koibuchi, FRONTIERS IN MOLECULAR NEUROSCIENCE, FRONTIERS IN MOLECULAR NEUROSCIENCE, 8, 05 , Refereed
  • Early-life stress increases the motility of microglia in adulthood, Yusuke Takatsuru, Junichi Nabekura, Tatsuya Ishikawa, Shin-ichi Kohsaka, Noriyuki Koibuchi, JOURNAL OF PHYSIOLOGICAL SCIENCES, JOURNAL OF PHYSIOLOGICAL SCIENCES, 65, (2) 187 - 194, 03 , Refereed
  • Early-life-stress affects the homeostasis of glutamatergic synapses, Syutaro Toya, Yusuke Takatsuru, Michifumi Kokubo, Izuki Amano, Noriaki Shimokawa, Noriyuki Koibuchi, EUROPEAN JOURNAL OF NEUROSCIENCE, EUROPEAN JOURNAL OF NEUROSCIENCE, 40, (11) 3627 - 3634, 12 , Refereed
  • Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism, N. Shimokawa, B. Yousefi, S. Morioka, S. Yamaguchi, A. Ohsawa, H. Hayashi, A. Azuma, H. Mizuno, M. Kasagi, H. Masuda, H. Jingu, S. -I. Furudate, A. Haijima, Y. Takatsuru, T. Iwasaki, M. Umezu, N. Koibuchi, JOURNAL OF NEUROENDOCRINOLOGY, JOURNAL OF NEUROENDOCRINOLOGY, 26, (3) 164 - 175, 03 , Refereed
  • Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder., Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru T, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N, Physiol. Rep, Physiol. Rep, 02 , Refereed
  • Contribution of neuronal and glial circuit in intact hemisphere for functional remodeling after focal ischemia, Yusuke Takatsuru, Junichi Nabekura, Noriyuki Koibuchi, NEUROSCIENCE RESEARCH, NEUROSCIENCE RESEARCH, 78, 38 - 44, 01 , Refereed, Invited
  • Compensatory contribution of the contralateral pyramidal tract after experimental cerebral ischemia., Takatsuru Y, Nakamura K, Nabekura J, Front Neurol Neurosci., Front Neurol Neurosci., 07 , Refereed, Invited
  • External negative electric potential accelerates exocytosis of lamellar bodies in human skin ex vivo, Junichi Kumamoto, Makiko Goto, Sumiko Denda, Masashi Nakatani, Yuya Takasugi, Katsunori Tsuchiya, Yuji Shimizu, Yusuke Takatsuru, Mitsuhiro Denda, EXPERIMENTAL DERMATOLOGY, EXPERIMENTAL DERMATOLOGY, 22, (6) 421 - 423, 06 , Refereed
  • Activity of the layer II/III neurons in the somatosensory cortex (SSC) plays a critical role on functional recovery after focal stroke in the contralateral SSC, Yusuke Takatsuru, Junichi Nabekura, Noriyuki Koibuchi, NEUROSCIENCE LETTERS, NEUROSCIENCE LETTERS, 543, 168 - 171, 05 , Refereed
  • Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke., Yusuke Takatsuru, Kei Eto, Ryosuke Kaneko, Hiroko Masuda, Noriaki Shimokawa, Noriyuki Koibuchi, Junichi Nabekura, The Journal of neuroscience : the official journal of the Society for Neuroscience, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, (11) 4683 - 92, 03 13 , Refereed
  • Studies of brain strokes using laser techniques - What we can do now, what we should do next -, Yusuke Takatsuru, The review of laser engineering, The review of laser engineering, 41, (2) 98 - 102, 02 , Refereed, Invited
  • PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia., Jie Shen, Yoko Ishii, Guihua Xu, Thanh Chung Dang, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yuichi Hattori, Yusuke Takatsuru, Junichi Nabekura, Masakiyo Sasahara, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32, (2) 353 - 67, 02 , Refereed
  • Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor., Lesmana R, Shimokawa N, Takatsuru Y, Iwasaki T, Koibuchi N, Environ Toxicol., Environ Toxicol., Refereed
  • Unilateral infarction of the visual cortex (VC) induced an increase in dendritic spine turnover in contralateral VC, Yusuke Takatsuru, Noriyuki Koibuchi, Junichi Nabekura, NEUROSCIENCE LETTERS, NEUROSCIENCE LETTERS, 488, (1) 97 - 100, 01 , Refereed
  • Maternal separation decreases the stability of mushroom spines in adult mice somatosensory cortex., Yusuke Takatsuru, Miki Yoshitomo, Tomomi Nemoto, Kei Eto, Junichi Nabekura, Brain research, Brain research, 1294, 45 - 51, 10 19 , Refereed
  • Functions of glutamate transporters in cerebellar Purkinje cell synapses, Y. Takayasu, M. Iino, Y. Takatsuru, K. Tanaka, S. Ozawa, ACTA PHYSIOLOGICA, ACTA PHYSIOLOGICA, 197, (1) 1 - 12, 09 , Refereed
  • Neuronal Circuit Remodeling in the Contralateral Cortical Hemisphere during Functional Recovery from Cerebral Infarction, Yusuke Takatsuru, Dai Fukumoto, Miki Yoshitomo, Tomomi Nemoto, Hideo Tsukada, Junichi Nabekura, JOURNAL OF NEUROSCIENCE, JOURNAL OF NEUROSCIENCE, 29, (32) 10081 - 10086, 08 , Refereed
  • The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex, Takatsuru Y, Fukumoto D, Yoshitomo M, Nemoto T, Tsukada H, Nabekura J, J. Phyisiol. Sci., J. Phyisiol. Sci., 59
  • Sustained depolarizing shift of the GABA reversal potential by glutamate receptor activation in hippocampal neurons., Kitamura A, Ishibashi H, Watanabe M, Takatsuru Y, Brodwick M, Nabekura J, Neuroscience research, Neuroscience research, 62, (4) 270 - 277, 12 , Refereed
  • Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses, Yusuke Takatsuru, Masae Iino, Kohichi Tanaka, Seiji Ozawa, NEUROSCIENCE LETTERS, NEUROSCIENCE LETTERS, 420, (1) 85 - 89, 06 , Refereed
  • Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses, Y Takatsuru, Y Takayasu, M Iino, O Nikkuni, Y Ueda, K Tanaka, S Ozawa, NEUROSCIENCE RESEARCH, NEUROSCIENCE RESEARCH, 54, (2) 140 - 148, 02 , Refereed
  • Predominant expression of GluR2 among the AMPA receptor subunits in neuronal progenitor cells of the rat hippocampus, N Hagimura, K Tsuzuki, M Iinoa, Y Takatsuru, Y Yoshida, S Kishi, S Ozawa, DEVELOPMENTAL BRAIN RESEARCH, DEVELOPMENTAL BRAIN RESEARCH, 152, (2) 213 - 223, 09 , Refereed

Misc

  • 慢性的なヨウ素摂取過剰による脳高次機能への影響, 天野出月, 高鶴裕介, はい島旭, 亀尾聡美, 原口省吾, 鯉淵典之, 日本内分泌学会雑誌, 95,   2019 04 01
  • PDGFR-βシグナルは脳虚血後の修復プロセスを促進する(PDGFR-β signal promotes repair process after cerebral ischemia), 申 杰, 石井 陽子, 徐 桂華, 濱島 丈, 松島 貴子, 山本 誠士, 高鶴 裕介, 鍋倉 淳一, 笹原 正清, 日本病理学会会誌, 100, (1) 347 - 347,   2011 03
  • 血小板由来増殖因子β受容体は脳虚血後の血管の成熟に重要である(The Involvement of PDGFR-β in the Maturation of Blood Vessel after Focal Cerebral Ischemia), 申 杰, 石井 陽子, 徐 桂華, 濱島 丈, 松島 貴子, 山本 誠士, 高鶴 裕介, 鍋倉 淳一, 笹原 正清, 神経化学, 49, (2-3) 507 - 507,   2010 08
  • 2光子励起顕微鏡によるin vivo imaging, 和氣弘明, 高鶴裕介, 根本知己, 鍋倉淳一, エクストリームフォトニクス研究-バイオイメージング 第5回理研・分子研合同シンポジウム 平成19年,   2007

Conference Activities & Talks

  • The Impact of Chronic Excess Iodine Intake in Adult Mice Behavior., Amano I, Takatsuru Y, Haijima A, Haraguchi S, Koibuchi N., Endo2020,   2020 03
  • Joint RANZCP/JSPN symposium: ‘Innovations in psychiatric continuing professional development’ Training for “hybrid” psychiatrist ~change the career from basic science to bed-side job~, Takatsuru Y, RANZCP2019,   2019 05
  • The effect of mild perinatal hypothyroidism in adult female mice behavior., Khairinisa MA, Takatsuru Y, Amano I, Koibuchi N., AOTA2016,   2017 03
  • Effects of perinatal mild hypothyroidism on learning and memory function of adult male offspring, Amano I, Takatsuru Y, Khairinisa MA, Kokubo M, Haijima A, Koibuchi N., AOTA2016,   2017 03
  • Iridium complex probe, BMTPDM1, is useful probe for in vivo imaging of oxygen dynamics., Takatsuru Y, Koibuchi N, Yoshihara T, Tobita M., 3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro-Device Engineering (GUMI&AMDE2016),   2016 12
  • Mild perinatal thyroid hormone insufficiency induced learning and memory disorders in adult mice., Amano I, Takatsuru Y, Khairinisa MA, Kokubo M, Haijima A, Koibuchi N, 4th Bandung International Biomolecular Medicine Conference,   2016 10
  • Cognitive function impairment in mouse model of mild perinatal hypothyroidism, Khairinisa MA, Takatsuru Y, Amano I, Koibuchi N., 4th Bandung International Biomolecular Medicine Conference,   2016 10
  • Aripiprazole improves the remodeling of neuronal circuit for functional recovery after stroke in somatosensory cortex, Obi K, Takatsuru Y, Amano I, Koibuchi N, 10th FENS,   2016 07
  • In vivo imaging of oxygen dynamics in aged-animal brain using iridium complex probe, Takatsuru Y, Koibuchi N, Yoshihara T, Tobita M., 7th International Conference on Advanced Micro-Device Engineering (AMDE2015),   2015 12
  • The neuronal and glial reorganization in the intact hemisphere contributes functional remodeling after focal stroke, Yusuke Takatsuru, Junichi Nabekura, Noriyuki Koibuchi, 8th FAOPS,   2015 11
  • Altered cerebellar development of mice deficient in dual oxidase maturation factors., Amano I, Takatsuru Y, Toya S, Haijima A, Iwasaki T, Grasberger H, Refetoff S, Koibuchi N, ATA 15th International Thyroid Congress,   2015 10
  • Early life stress induced the retardation of cerebellar function in adulthood, Takatsuru Y, Kokubo M, Toya S, Amano I, Koibuchi N., 7th international symposium of SRC,   2015 05
  • Disruption of Glucocorticoid Homeostasis and Glutamatergic Neuronal Circuit in Adulthood of Male Mice By Maternal Deprivation, Koibuchi N, Toya S, Amano I, Shimokawa N, Takatsuru Y, ENDO2015,   2015 03
  • In vivo deep, red color imaging using advanced multi-photon laser microscopy (FVMPE-RS, Olympus), Takatsuru Y, Kaneko R, Kominato Y, Noriyuki K, International Society of Radiation Neurobiology 5th Conference,   2015 02
  • In vivo imaging of oxygen dynamics using Iridium complex probe, Takatsuru Y, Koibuchi N, Yoshihara T, Tobita M., 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering (GUMI&AMDE2014),   2014 12
  • Cerebellar ataxia in dual oxidase maturation factor (DUOXA) mutant mice, Amano I, Takatsuru Y, Toya S, Haijima A, Koibuchi N, 3rd Bandung International biomolecule medicine conference,   2014 09
  • Early life stress affects the homeostasis of glutamatergic neuronal circuit, Takatsuru Y, Toya S, Amano I, Shimokawa N, Koibuchi N, 9th FENS,   2014 07
  • 脳発達におけるPerfluorooctane sulfonate (PFOS)とPerfluorooctanoic acid (PFOA)の影響, Iwasaki et, 87th annualmeeting of Japan endcrine society,   2013 04 24
  • Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid (rdw) rat, Hayashi et a, The 90th annual meeting for the physiological society of Japan,   2013 03
  • Aberrant cerebellar development of mice deficient in dual oxidase matuirration factors (DUOXA), Amano I, Takatsuru Y, Haijima A, Koibuch N, The 90th annual meeting for the physiological society of Japan,   2013 03
  • Maternal behavior of female mice exposed to early life stress, MItani S, Takatsuru Y, Amano I, Koibuchi N, The 90th annual meeting for the physiological society of Japan,   2013 03
  • The moelcular mechanism of early life stress for synaptic instability in somatosensory coretx, Toya S, Takatsuru Y, Amano I, Koibuchi N, The 90th annual meeting for the physiological society of Japan,   2013 03
  • Role of the glial glutamate transporters for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke, Takatsuru Y, Kaneko R, Shimokawa N, Nabekura J, Koibuchi N, The 90th annual meeting of the physiological society of Japan,   2013 03
  • Early life stress induced synaptic instability and molecular changes in somatosensory cortex., Takatsuru Y, Toya S, Amano I, Nabekura J, Koibuchi N, The 23rd CDB meeting: Building multicellular systems from cellular cross-talk,   2013 01
  • Study of chronic stress model mice using in vivo microdialysis, Yusuke Takatsuru, The 23th microdialysis meeting,   2012 12
  • The early life stress induced synaptic instability in somatosensory cortex., Takatsuru Y, Toya S, Amano I, Nabekura J, Koibuchi N, International Synapse Research Workshop 2012,   2012 11
  • Aberrant cerebellar development in dual oxidase maturation factor (DUOXA) knockout mice, Izuki Amano, Yusuke Takatsuru, Asahi Haijima, Noriyuki Koibuchi, AOTA2012,   2012 10
  • The mechanism of maternal-separation stress for synaptic instability in somatosensory cortex, Yusuke Takatsuru, Shu-taro Toya, Hiroko Masuda, Izuki Amano, Noriyuki Koibuchi, Junichi Nabekura, Neurosicence 2012,   2012 09
  • Synaptic instability is induced by Mmaternal -separation in somatosensory cortex., Yusuke Takatsuru, Shu-taroh, Toya, Junichi Nabekura, Noriyuki Koibuchi, 8th FENS,   2012 07
  • Maternal exposure of OH-PCB causes hyperactivity in neonatal rats, Yusuke TakatsuruYusuke Takatsuru, Shu-taro Toya, Hiroko Masuda, Izuki Amano, Noriyuki Koibuchi, Junichi Nabekura, The 89th annual meeting of the physiological society of Japan,   2012 03
  • Maternal exposure of OH-PCB causes hyperactivity in neonatal rats., N. Shimokawa, R. Tosmana, Y. Takatsuru, T. Iwasaki, N. Koibuchi, The 14th annual meeting of Japan society of endocrine disrupters research.,   2011 12
  • Maternal exposure to a PCB metabolite (OH-PCB106) induces hyperactive disorder in neonatal rats., N. Koibuchi, R. Ronny, T. Iwasaki, Y. Takatsuru, N. Shimokawa, Neuroscience2011,   2011 11
  • Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat, Sayo Yamaguchi, Asuka Ohsawa, Behnaz Yousefi, Shiori Morioka, Hiroko Masuda, Ronny Ronny, Hideka Hayashi, Yusuke Takatsuru, Toshiharu Iwasaki, Noriaki Shimokawa, Motoaki Umezu, Noriyuki Koibuchi, 4th International Symposium, Society for Research on the Cerebellum,   2011 09
  • Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction., Yusuke Takatsuru, Noriyuki Koibuchi, Junichi Nabekura, The 34th Annual meeting of the Japan Neuroscience Society.,   2011 09
  • PDGFR- β is essential for recruitment, but not for survival of pericyte in adult, Jie Shen, Yoko Ishii, Guihua Xu, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yuichi Hattori, Yusuke Takatsuru, Junichi Nabekura, Masakiyo Sasahara, The 34th Annual meeting of the Japan Neuroscience Society.,   2011 09
  • Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat, Sayo Yamaguchi, Asuka Ohsawa, Hiroko Masuda, Yusuke Takatsuru, Noriaki Shimokawa, Noriyuki Koibuchi, The 88th Annual meeting of the Physiological Society of Japan,   2011 03
  • Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction, Yusuke Takatsuru, Noriyuki Koibuchi, Junichi Nabekura, The 88th Annual meeting of the Physiological Society of Japan,   2011 03
  • Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex., Takatsuru, Y, Fukumoto, D, Yoshitomo, M, Nemoto, T, Tsukada, H, Koibuchi, N, Nabekura, J, 7th FENS,   2010 07
  • The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex., Takatsuru, Y, Fukumoto, D, Yoshitomo, M, Nemoto, T, Tsukada, H, Nabekura, J, IUPS2009,   2009 07
  • The dendritic spine of layer V pyramidal neuron in contralateral area of focal ischemia was actively remodeling in somatosensory cortex., Yusuke TakatsuruYusuke Takatsuru, Tomomi Nemoto, Junichi Nabekura, Neuroscience 2008,   2008 11
  • The stress of mother-separation cause significant effects for development of dendritic spines in layer V pyramidal neuron in motor cortex., Yusuke Takatsuru, Junichi Nabekura, The 31th Annual meeting of the Japan Neuroscience Society.,   2008 07
  • Functional roles of glutamate transporters in cerebellar Purkinje cell synapses, Iino, M, Takayasu, Y, Takatsuru, Y, Ozawa, S, The 85th Annual meeting of the Physiological Society of Japan,   2008 03
  • Regulation of excitatory synaptic transmisson by glial glutamate transporters, Takatsuru, Y, Takayasu, Y, Iino, M, Ozawa, S, The 29th Annual meeting of the Japan Neuroscience Society,   2006 07
  • Regulation of excitatory synaptic transmission by glial glutamate transporters, Takatsuru, Y, Takayasu, Y, Iino, M, Ozawa, S, The 83nd Annual meeting of the Physiological Society of Japan.,   2006 03
  • glutamate transporter, GLT-1, in climbing fibber-Purkinje cell synapses in the cerebellum., Yusuke TakatsuruTakatsuru, Y, Takayasu, Y, Nikkuni, O, Iino, M, Ozawa, S, The 82nd Annual meeting of the Physiological Society of Japan.,   2005 05
  • C-terminal cytoplasmic domain for expression of functional NMDA receptors in PC12 cells, Yusuke TakatsuruTakatsuru, Y, Tsuzuki, K, Okado, H, Miwa A, Ozawa, S, The 81st Annual meeting of the Physiological Society of Japan,   2004 06

Awards & Honors

  •   2013 03 , Physiological society of Japan, Kiichi Sagawaaward

Research Grants & Projects

  • Analysis of activity-dependent dynamics of NMDA receptors in mice with age-dependent synaptic dysfunction, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, In vivo imaging by using two-photon laser microscopy under deep anesthesia revealed dendritic spine morphology of pyramidal neurons in the cerebral cortex of transgenic mice expressing GFP under the control of Thy1-promoter. Analysis of heterozygotes of knockout mice deficient in drebrin A-specific exon or all drebrin isoforms tended to show some changes in turnover rate of dendritic spines compared with wild-type mice. The amount of NMDA receptors in synaptosomes were detected by western blotting.
  • Neuronal remodeling after focal stroke induced by astrocyte stimulation, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), In this study, we observed the role of astrocyte on remodeling for functional compensation in contralateral hemisphere of focal stroke. We found that dopamine is one of the strong candidate for contributing the functional remodeling/recovery after focal stroke. We also found that repetitive application of Aripiprazole, one of the partial agonist for dopamine receptor, enhances the remodeling of neuronal circuit in intact hemisphere after focal stroke. Since the Aripiprazole enhances the activity of astrocyte if it repetitively applied, our study suggested that application of aripiprazole enhances the neuronal remodeling after focal stroke via activation of dopaminergic systems.
  • Effects of environmental factors on small lipophilic hormone-mediated development of brain function, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), This study was designed to examine the effect of the alteration of nuclear receptor-mediated gene expression on brain development. Using in vivo preparation, we found that congenital hypothyroid mouse and rat showed cerebellar ataxia. Electrophysiological study showed that such alteration may be induced by an aberrant synaptic function between parallel fiber and Purkinje cell. Perinatal PCB treatment induced the similar phenotype. Using in vitro preparation, we established the primary culture system of the hippocampus to study the effect of thyroid hormone. In addition, we examined the affect of gadolinium-based contrast agents (GBCA) on thyroid hormone action and found that linear GBCA disrupted thyroid hormone receptor action and thyroid hormone-mediated cerebellar dendritogenesis of Purkinje cell.
  • Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.
  • Mechanism of remodeling and functional compensation after stroke in intact hemisphere, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Remodeling and/or synapse plasticity is increased at 1^ week after stroke in intact hemisphere. In contrast, recovery of general behavior is delay compared with those in simple somatosensory function. During the remodeling, glutamine, glysine and dopamine seems to be play an important role. Application of haloperidol at 2-4 days after stroke prolongs the recovery.
  • Regulation of K-Cl transporter and modal shift of GABA response in development and recovery., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, The neuronal K(+)-Cl(-) cotransporter (KCC2) is a membrane transport protein that extrudes Cl(-) from neurons and helps maintain low intracellular [Cl(-)] and hyperpolarizing GABAergic synaptic potentials. Depolarizing gamma-aminobutyric acid (GABA) responses in neonatal neurons and following various forms of neuronal injury are associated with reduced levels of KCC2 expression. Mutation to the putative tyrosine phosphorylation site within the long intracellular carboxyl terminus of KCC2(Y1087D) or application of the tyrosine kinase inhibitor genistein shifted the GABA reversal potential (E(GABA)) to more depolarized values, indicating reduced KCC2 function. This was associated with a change in the expression pattern of KCC2 from a punctate distribution to a more uniform distribution, suggesting that functional tyrosine-phosphorylated KCC2 forms clusters in restricted membrane domains. A tyrosine phosphatase inhibitor increased the proportion of KCC2 associated with lipid rafts membrane domains. These results indicate that direct tyrosine phosphorylation of KCC2 results in membrane clusters and functional transport activity. Oxidative stress resulted in a rapid dephosphorylation of KCC2 that preceded the decreases in KCC2 protein or mRNA expression. Dephosphorylation of KCC2 is correlated with a reduction of transport activity and a decrease in [Cl-]i, as well as a reduction in KCC2 surface expression. Manipulation of KCC2 tyrosine phosphorylation resulted in altered neuronal viability in response to in vitro oxidative stress. We propose that neuronal stress induces a rapid loss of tyrosine phosphorylation of KCC2 that results in translocation of the protein and functional loss of transport activity.
  • Functional implication of transmitter switching of inhibitory Circuits., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  • In vivo imaging of neuron・glia during the recovery from infarction by using two-photon laser microscopy, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)