Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2015/04 -2018/03
Author : Nishimura Taisuke; KATOH Etsuko; Tran Hien Linh; NOGAWA Shogo; YUKAWA Yusuke; ARAKAKI Makoto; HIRASAWA Tatsumi; KUGO Takamasa; HOSHINO Ami; SATO Takuma; YAMAMOTO Marie
MOM1, a silencing factor in Arabidopsis thaliana, is predicted to act downstream of DNA methylation in gene expression due to the phenotype of its loss of function mutants. By genetic and biochemical approaches, we identified new factors which function in the same pathway as MOM1 in gene regulation. Since the factors involved in addition or elimination of SUMO, which is one of protein modifications, were included among them, we hypothesized that SUMOylation in some proteins would be important as a downstream mechanism of DNA methylation in gene expression.