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Naoko Ando

    Department of Applied Chemistry　Professor
    Research Institute of Industrial Technology　Researcher
    Course of Applied Chemistry　Professor
    Bio-Nano Electronics Research Center　Researcher
Last Updated :2025/04/19

Researcher Information

Alias Name

    Naoko Takahashi-Ando

URL

Research funding number

  • 70360485

J-Global ID

Research Interests

  • マイコトキシン   トリコテセン   解毒微生物   phytochemical   精油   

Research Areas

  • Life sciences / Food sciences

Academic & Professional Experience

  • 2015/04 - Today  Toyo UniversityFaculty of Science and Engineering教授
  • 2009/04 - 2015/03  Toyo UniversityFaculty of Science and Engineering准教授
  • 2008/04 - 2015/03  Toyo University工学部准教授
  • 2000/10 - 2008/03  理化学研究所植物科学センター研究員
  • 1996/05 - 2000/09  日本たばこ産業生物分子工学研究プロジェクトチーム研究員
  • 1994/04 - 1996/04  Battelle Northwest lab.Post-doctral fellow

Education

  • 1988/09 - 1994/03  Oregon State University  Department of Food Science and Technology  Food Toxicology
  • 1987/04 - 1988/08  Ochanomizu University  家政学研究科  食物学専攻
  • 1983/04 - 1987/03  Ochanomizu University  家政学部  食物学科

Published Papers

MISC

Industrial Property Rights

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2021/04 -2024/03 
    Author : 安藤 直子; 木村 真
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/04 -2021/03 
    Author : Takahashi-Ando Naoko
     
    Trichothecenes are a group of mycotoxins that contain trichothecene skeleton in common. They are produced when filamentous fungi such as Fusarium spp. infect wheat and other important crops. Recently, a series of studies reported previously unknown trichothecenes such as newly evolved trichothecenes and conjugated trichothecenes. These novel trichothecenes might not be able to be detected by conventional methods, thus, can pose a major threat to food safety. Therefore, in this study, we aimed to create an MS/MS library of various trichothecenes including novel ones, so that we can detect and identify newly evolved trichothecenes emerged in the field. In this study, we created and identified several analogs of T-2 toxin, which is highly toxic and frequently found in agricultural products in Japan. We also succeeded to produce and identify novel glucose conjugates of trichothecenes. These results are expected to contribute to build a novel food safety inspection system.
  • 新規カビ毒の探索・創出と先進的な食の安全検査体制の整備に向けた基盤研究
    文部科学省：科学研究費補助金（基盤研究(C)）
    Date (from‐to) : 2018/04 -2020/03 
    Author : 安藤 直子
  • 皮膚恒常性維持に寄与する精油の選抜とその作用の解明〜ヒト表皮培養細胞を用いて〜
    アロマ環境協会：学術研究助成
    Date (from‐to) : 2018/04 -2019/03 
    Author : 安藤 直子
  • マイクロ皮膚モデルを用いるトリコテセンの皮膚抗炎症効果の検討
    日本私立学校振興・共済事業団：学術研究振興資金 学術研究助成
    Date (from‐to) : 2018/04 -2019/03 
    Author : 安藤 直子
  • カビ毒トリコテセンアセチル化酵素の謎解明と簡易検出系への応用
    飯島記念食品科学振興財団：学術研究助成
    Date (from‐to) : 2016/04 -2017/03 
    Author : 木村 真
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2015 -2017 
    Author : Naoko Takahashi-Ando
     
    Filamentous fungi such as Fusarium graminearum produce trichothecene mycotoxins including nivalenol (NIV). However, since effective antibodies necessary for ELISA to detect NIV-type trichothecenes have not been obtained yet, these mycotoxins are not regulated properly. Thus, we assumed that NIV-type trichothecenes can be converted to 3,4,15-triacetylnivalenol by acetylase, and this product can be measured by ELISA. In this study, we attempted to acquire enzymes that acetylate at positions C-3, C-4, and C-15 of NIV-type trichothecenes, from F. graminearum we purchased and modified by genetic engineering, and soil microorganisms we screened for. We succeeded in finding the proper conditions for collective conversion of NIV-type trichothecenes to 3,4,15-triacetylnivalenol, which is detectable by ELISA. This research may contribute to the construction of a collective detection system of NIV-type trichothecenes.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2015/03 
    Author : HOMMA Seiichi; YAMAGUCHI Keiko; MATSUI Yoshimitsu; OTSUKA Yuzuru; NAKANISHI Yasuhiro; SUZUKI Emiko; ANDO Naoko; NOMI Yuri
     
    We have found out a few effective micro-organisms that can decompose melanoidin polymers to detect the molecular structure by summing the chemical characteristics of the decomposition products. The micro-organism samples were collected mainly from sugarcane farm and mangrove floor soil in the Ryukyu Archipelago.The sugarcane was decomposed by the sample obtained in Miyako Island. Those samples showed laccase activity. Mechanism of maillard reaction was investigated. Maillard reaction products were introduced to cell or animals and effect of those compounds on gene expression was measured. New method to analyze MI, PhIP, Pyrazines, CML, CEL etc with LC-MS/MS was established and contents of those products in foods were analyzed and the results were stored in database.
  • カビ毒トリコテセンアセチル化酵素の謎解明と簡易検出系への応用
    飯島記念食品科学振興財団：学術研究助成
    Date (from‐to) : 2014/04 -2015/03 
    Author : 安藤 直子
  • カビ毒トリコテセン生産菌の自己耐性機構の証明と防除への応用
    公益財団法人食生活研究会：研究助成
    Date (from‐to) : 2014/04 -2015/03 
    Author : 安藤 直子
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2011 -2013 
    Author : ANDO Naoko; MINEGISHI Hiroaki
     
    Trichothecenes are mycotoxins which are produced by Fusarium and other genera. They contaminate important crops, and can cause serious health problems in humans and livestock. In this research, we found 22 trichothecene resistance genes in Saccharomyces cerevisiae. We constructed multiple gene deletion mutants, and among them, the triple mutant which deleted pdr5, erg6, and rpb4, showed the highest sensitivity toward various trichothecenes. We constructed an effective detective system using disc diffusion test, which allows us to detect deoxynivalenol contaminated with the provisional level in wheat and wheat flower. Next, we screened for microoganisms which can detoxify T-2 toxin, deoxynivalenol and 4-acetylnivalenol. We collected ~10,000 microorganisms mainly from soil, and we found that there were more than 10% microorganisms can deacetylate T-2 toxin and 4-acetyl nivalenol, which resulted in reducing toxicity. However, no organisms can detoxify deoxynivalenol.
  • 小麦に混入するカビ毒の生物学的簡易検出法の構築
    飯島記念食品科学振興財団：学術研究助成
    Date (from‐to) : 2010/04 -2011/03 
    Author : 安藤 直子
  • 重要穀類を汚染するカビ毒トリコテセンの簡易検出法の構築
    東洋食品研究所：学術研究助成
    Date (from‐to) : 2010/04 -2011/03 
    Author : 安藤 直子
  • アトピー性皮膚炎の成人患者支援スキームづくりのための基礎研究；患者の「困難」の構造的・歴史的理解と支援方針の検討のために
    高木仁三郎市民科学基金：調査研究助成
    Date (from‐to) : 2006/04 -2007/03 
    Author : 安藤 直子

Social Contribution

  • 高木仁三郎市民科学基金
    Role : Advisor
    Category : Investigation

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