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萩尾 真人ハギオ マサヒト

所属・担当
生命科学部
職名助教
メールアドレスhagio[at]toyo.jp ※[at]を@に書き換えて送信して下さい
ホームページURLhttp://www2.toyo.ac.jp/~hagio/
生年月日
Last Updated :2017/07/19

研究者基本情報

学歴

  •  - 2010年, 北海道大学, 農学研究科, 応用生物化学
  •  - 2003年, 北海道大学, 農学部, 生物機能科学科

学位

  • 博士(農学), 北海道大学

研究活動情報

研究分野

  • 農芸化学, 食品科学
  • 基礎医学, 病態医化学

研究キーワード

    胆汁酸, 大腸癌, 膵癌, LC/MS

論文

  • Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats., Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T, PloS one, 9, (4) ,   2014年04月
  • Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation., Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Fukiya S, Hara H, Yokota A, Ishizuka S, Toxicology letters, 232, (1) 246 - 252,   2014年10月
  • Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71., Matsuda Y, Ishiwata T, Yoshimura H, Hagio M, Arai T, Cancer letters, 357, (2) 602 - 611,   2015年02月
  • Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone., Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Hagio M, Lee JY, Fukiya S, Yokota A, Ishizuka S, Miyazaki H, Bioscience, biotechnology, and biochemistry, 79, (6) 1 - 6,   2015年03月
  • Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells., Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S, Journal of nutritional science and vitaminology, 60, (6) 450 - 454,   2014年
  • Is bile acid a determinant of the gut microbiota on a high-fat diet?, Yokota A, Fukiya S, Islam KB, Ooka T, Ogura Y, Hayashi T, Hagio M, Ishizuka S, Gut microbes, 3, (5) 455 - 459,   2012年09月
  • Nestin regulates epithelial-mesenchymal transition marker expression in pancreatic ductal adenocarcinoma cell lines., Hagio M, Matsuda Y, Suzuki T, Ishiwata T, Molecular and clinical oncology, 1, (1) 83 - 87,   2013年01月
  • Nestin: a novel angiogenesis marker and possible target for tumor angiogenesis., Matsuda Y, Hagio M, Ishiwata T, World journal of gastroenterology, 19, (1) 42 - 48,   2013年01月
  • Contribution of dipeptidyl peptidase IV to the severity of dextran sulfate sodium-induced colitis in the early phase., Iwaya H, Fujii N, Hagio M, Hara H, Ishizuka S, Bioscience, biotechnology, and biochemistry, 77, (7) 1461 - 1466,   2013年
  • Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells., Matsuda Y, Hagio M, Seya T, Ishiwata T, Molecular cancer therapeutics, 11, (9) 2010 - 2020,   2012年09月
  • Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas., Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T, International journal of oncology,   2012年07月
  • Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to γ-rays., Ishizuka S, Shiwaku M, Hagio M, Suzuki T, Hira T, Hara H, Biomedical research (Tokyo, Japan), 33, (3) 159 - 165,   2012年06月
  • Clinicopathological features of 30 autopsy cases of pancreatic carcinoma., Matsuda Y, Hagio M, Naito Z, Ishiwata T, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 79, (6) 459 - 467,   2012年
  • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats., Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A, Gastroenterology, 141, (5) 1773 - 1781,   2011年11月
  • Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer., Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z, Cancer letters, 309, (2) 209 - 219,   2011年10月
  • Bile acid analysis in various biological samples using ultra performance liquid chromatography/electrospray ionization-mass spectrometry (UPLC/ESI-MS)., Hagio M, Matsumoto M, Ishizuka S, Methods in molecular biology (Clifton, N.J.), 708, 119 - 129,   2011年
  • Inulin prolongs survival of intragastrically administered Lactobacillus plantarum No. 14 in the gut of mice fed a high-fat diet., Takemura N, Hagio M, Ishizuka S, Ito H, Morita T, Sonoyama K, The Journal of nutrition, 140, (11) 1963 - 1969,   2010年11月
  • Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces., Hagio M, Matsumoto M, Yajima T, Hara H, Ishizuka S, Journal of applied physiology (Bethesda, Md. : 1985), 109, (3) 663 - 668,   2010年09月
  • Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats., Matsumoto M, Hosokawa M, Matsukawa N, Hagio M, Shinoki A, Nishimukai M, Miyashita K, Yajima T, Hara H, European journal of nutrition, 49, (4) 243 - 249,   2010年06月

MISC

  • Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer; a potential therapeutic target in colorectal cancer., Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng W, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z., Cancer Lett., in press
  • Voluntary wheel-running exercise and dietary lactose concomitantly reduce the proportion of secondary bile acids in rat feces., Hagio M, Matsumoto M, Yajima T, Hara H, Ishizuka S., J Appl Physiol., 109, (3) 663 - 668,   2010年
  • Inulin prolongs survival of intragastrically administered Lactobacillus plantarum no. 14 in the gut of mice fed a high-fat diet., Takemura N, Hagio M, Ishizuka S, Ito H, Morita T, Sonoyama K., J Nutr., 140, (11) 1963 - 1969,   2010年
  • Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats., Matsumoto M, Hosokawa M, Matsukawa N, Hagio M, Shinoki A, Nishimukai M, Miyashita K, Yajima T, Hara H., Eur J Nutr., 49, (4) 243 - 249,   2010年
  • Nondigestible Saccharides Suppress the Bacterial Degradation of Quercetin Aglycone in the Large Intestine and Enhance the Bioavailability of Quercetin Glucoside in Rats., Matsukawa N, Matsumoto M, Shinoki A, Hagio M, Inoue R, Hara H., J Agric Food Chem., 57, (20) 9462 - 9468,   2009年
  • Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS., Hagio M, Matsumoto M, Fukushima M, Hara H, Ishizuka S., J Lipid Res., 50, (1) 173 - 180,   2009年
  • Relationship between formation of aberrant crypts and acute responses of colonic epithelial cells to genotoxic treatment among inbred rat strains., Ishizuka S, Takeuchi A, Hagio M, Mohara M, Sakai H, Yamada K., Cancer Lett., 196, (2) 135 - 41,   2003年
  • Bile acid analysis in various biological samples using ultra performance liquid chromatography/electrospray-mass spectrometry (LC/ESI-MS)., Hagio M, Matsumoto M, Ishizuka S., Methods in molecular biology.,   2011年

競争的資金

  • LC/MSを用いた膵癌組織中nestinタンパク定量法の検討, 共同研究