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SIIZAKI Kazuhiro

Faculty
Department of Applied Biosciences
Research Institute of Industrial Technology
PositionAssociate Professor
Mail
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Birthday
Last Updated :2017/11/11

Researcher Profile and Settings

Education

  •   2002 04  - 2006 03 , University of Tsukuba

Association Memberships

  • THE JAPANESE CANCER ASSOCIATION

Research Activities

Research Areas

  • Environmental science, Risk sciences of radiation and chemicals
  • Biological science, Molecular biology
  • Pharmacy, Medical pharmacy

Research Interests

    AhR, Carcinogenesis

Published Papers

  • Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane., Akiba N, Shiizaki K, Matsushima Y, Endo O, Inaba K, Totsuka Y, Mutagenesis, 05
  • Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor., Shiizaki K, Kawanishi M, Yagi T, Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 39
  • Development of yeast reporter assays for the enhanced detection of environmental ligands of thyroid hormone receptors α and β from Xenopus tropicalis., Matsui S, Ito-Harashima S, Sugimoto Y, Takada E, Shiizaki K, Kawanishi M, Yagi T, Toxicology in vitro : an international journal published in association with BIBRA, 37, 15 - 24, 12
  • Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes., Ito-Harashima S, Shiizaki K, Kawanishi M, Kakiuchi K, Onishi K, Yamaji R, Yagi T, Journal of pharmacological and toxicological methods, 74, 41 - 52, 07
  • Microbial Metabolites of Omeprazole Activate Murine Aryl Hydrocarbon Receptor In Vitro and In Vivo., Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi, Drug Metab Dispos., 42, (10) 1690 - 1697, 10
  • Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes, Kazuhiro Shiizaki, Tomoya Yoshikawa, Eiji Takada, Shizuma Hirose, Sayoko Ito-Harashima, Masanobu Kawanishi, Takashi Yagi, 69, (2) 245 - 252, 03
  • Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands, Kazuhiro Shiizaki, Seiichiroh Ohsako, Masanobu Kawanishi, Takashi Yagi, Molecular Pharmacology, 85, (2) 279 - 289
  • ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice., Ikuta T, Kobayashi Y, Kitazawa M, Shiizaki K, Itano N, Noda T, Pettersson S, Poellinger L, Fujii-Kuriyama Y, Taniguchi S, Kawajiri K, Carcinogenesis, 34, (7) 1620 - 1627, 07
  • Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 750, (1-2) 77 - 85, 01
  • Establishment of Yeast Reporter Assay Systems to Detect Ligands of Thyroid Hormone Receptors alpha and beta., Kazuhiro Shiizaki, Shota Asai, Shingo Ebata, Masanobu Kawanishi, Takashi Yagi, Toxicol In Vitro., 24, (2) 638 - 44
  • Validation of a new yeast-based reporter assay consisting of human estrogen receptors alpha/beta and coactivator SRC-1: application for detection of estrogenic activity in environmental samples., Chu WL, Shiizaki K, Kawanishi M, Kondo M, Yagi T, Environmental toxicology, 24, (5) 513 - 521, 10
  • Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats., Kawakami T, Ito T, Ohsako S, Shiizaki K, Murakami Y, Hirowatari K, Sato M, Tohyama C, The Journal of toxicological sciences, 34, (2) 209 - 220, 04
  • Differential response of various pharmaceuticals to human estrogen receptor a and b in newly-constructed yest reporter assays. , Chu WL, Shiizaki K, Kawanishi M, Kondo M. Yagi T,, Genes and Environment, 31, (3) 80 - 86
  • Construction of a reporter yeast strain to detect estrogen receptor signaling through aryl hydrocarbon receptor activation., Kawanishi M, Kondo M, Shiizaki K, Chu WL, Terasoma Y, Yagi T, Environmental science & technology, 42, (18) 6897 - 6902, 09
  • Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells., Kazuhiro Shiizaki, Seiichiro Osako, Masanobu Kawanishi, Takashi Yagi, Basic Clin Pharmacol Toxicol., 103, (5) 468 - 75
  • Identification of amino acid residues in the Ah receptor involved in ligand binding., Goryo K, Suzuki A, Del Carpio CA, Siizaki K, Kuriyama E, Mikami Y, Kinoshita K, Yasumoto K, Rannug A, Miyamoto A, Fujii-Kuriyama Y, Sogawa K, Biochemical and biophysical research communications, 354, (2) 396 - 402, 03
  • Activation of telomerase in BeWo cells by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin in co-operation with c-Myc., Sarkar P, Shiizaki K, Yonemoto J, Sone H, International journal of oncology, 28, (1) 43 - 51, 01
  • Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin., Kazuhiro Shiizaki, Seiichiro Ohsako, Toshie Koyama, Ryoji Nagata, Junzo Yonemoto, Chiharu Tohyama, 160, (1) 22 - 33, 12
  • Identification of differentially expressed gene in ovariectomized rat pituitary normalized by Unkei-to. Res Commun. Pharmcology and Toxicology. , Shiizaki K, Goto K, Ishige A., Res Commun. Pharmcology and Toxicology., 6, (1,2) 125 - 133, 01
  • Antinociceptive effect of U-50488H, a kappa-opioid agonist, in streptozotocin-induced diabetic mice., Suzuki Y, Goto K, Shiizaki K, Omiya Y, Ishige A, Komatsu Y, Kamei J., J Pharm Pharmacol., 53, (4) 521 - 526
  • Phytoestrogen activity of Emodin, an anthraquinone derivative isolated from Rheum palamatum., Shiizaki K, Muramatsu M, Ogawa S, Inoue S, Goto K, Ishige A, Sasaki H. , Res Commun. Pharmcology and Toxicology., 5, (3,4) 179 - 189, 03
  • Bioassay of phytoestrogen in herbal medicine used for postmenopausal disorder using transformed MCF-7 cells., Kazuhiro Shiizaki, Kazuhiro Goto, Atsushi Ishige, Yasunori Komatsu, Phytother Res., 13, (6) 498 - 503, 09

Patents

  • 特願2008-079803, 特許第5226353号

Research Grants & Projects

  • Discovery of the novel AhR ligand from a natural product